The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Effect of Herba Ephedrae on Airway hyperreactivity

마황(麻黃)의 기도과민반응의 효과

  • Lee, Seong-Cheol (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Park, Sung-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Seo, Sang-Wan (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Hwang, Sang-Wook (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Yong-Woo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Song, Dal-Soo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Chae, Younh-Seok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Shin, Min-Kyo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Song, Ho-Joon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
  • 이성철 (원광대학교 한의과대학 본초학교실) ;
  • 박성주 (원광대학교 한의과대학 본초학교실) ;
  • 서상완 (원광대학교 한의과대학 본초학교실) ;
  • 황상욱 (원광대학교 한의과대학 본초학교실) ;
  • 김영우 (원광대학교 한의과대학 본초학교실) ;
  • 송달수 (원광대학교 한의과대학 본초학교실) ;
  • 채영석 (원광대학교 한의과대학 본초학교실) ;
  • 신민교 (원광대학교 한의과대학 본초학교실) ;
  • 송호준 (원광대학교 한의과대학 본초학교실)
  • Published : 2005.12.30
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Abstract

Objectives : HERBA EPHEDRAE (HE) has been used cough and asthma for long time in korea. In the present study, we examined the effect HE on the ovalbumin (OVA)-induced airway hyper-reactivity (AHR). Methods : To examine the effect of HE on AHR, mice were sensitized with 100 mg of OVA and 1mg of alum intraperitoneally on day 0 and 14. On day 28, mice were challenged on 3 consecutive days with 3% OVA and AHR was assessed 24 h after the last challenge. To examine severity of airway hyper-reactivity, we examined eosinophil population and cytokine production in bronchoaveloar lavage fluid(BALF) and stained with hematoxylin and eosin in lung. Results : HE potently inhibited the development of airway hyper-reactivity and also reduced the number of eosinophil during OVA-induced airway hyper-reactivity. HE also inhibited cytokines production such as IL-4, IL-5, IL-13 in BALF. Furthermore, HE inhibited proliferation of eosinophil in a dose dependent manner. Conclusions : These results suggest that HE may be beneficial oriental medicine for AHR.

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