The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Anti-aging Effect on Skin with the needles of red pine, Pinus densiflora

적송엽(赤松葉)이 피부(皮膚)의 노화(老化)에 미치는 영향(影響)

  • Park, Seong-Kyu (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER,Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Jong-Chan (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
  • Ahn, Soo-Mi (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
  • Lee, Jin-Young (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
  • Kim, Youn-Joon (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
  • Hwang, Jae-Sung (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
  • Lee, Byeong-Gon (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
  • Chang, Ih-Seoup (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER)
  • 박성규 ((주)태평양 기술연구원 피부과학연구소,경희대학교 한의과대학 방제학교실) ;
  • 이종찬 ((주)태평양 기술연구원 피부과학연구소) ;
  • 안수미 ((주)태평양 기술연구원 피부과학연구소) ;
  • 이진영 ((주)태평양 기술연구원 피부과학연구소) ;
  • 김연준 ((주)태평양 기술연구원 피부과학연구소) ;
  • 황재성 ((주)태평양 기술연구원 피부과학연구소) ;
  • 이병곤 ((주)태평양 기술연구원 피부과학연구소) ;
  • 장이섭 ((주)태평양 기술연구원 피부과학연구소)
  • Published : 2005.12.30
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Abstract

Objectives : We investigated the anti-aging effect on skin with the extract of the needles of red pine, Pinus densiflora. Methods : We measured various effects related to skin such as the anti-oxidant effect, the protection against ultraviolet (UV) irradiation, the inhibition of reactive oxygen species (ROS) generation, the induction of heat shock protein 70 (HSP70), the reduction of matrix metalloproteinase-2 (MMP-2) synthesis and senescent cell. Results : The results were as follows : The extract of the needles of red pine (RP) had the potent anti-oxidant effect and the ROS scavenging effect. Also RP preserved the systemic anti-oxidant enzyme system (superoxide dismutase and catalase) from UVB irradiation. RP protected the cell membrane from the damages induced by UVB irradiation. RP induced HSP70, a mediator of resistance to UVB irradiation. RP reduced the synthesis of MMP-2 induced by UVB irradiation. And RP inhibited the amount of senescent-associated (SA) ${\beta}-galactosidase$ staining, as a marker of replicative senescence. Conclusions : The results of our study indicate that the extract of the needles of red pine, Pinus densiflora, has anti-aging effects on skin.

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