대한예방한의학회지 (Journal of Society of Preventive Korean Medicine)

대한예방한의학회 (Society of Preventive Korean Medicine)
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고삼에서 항균물질의 분리

Isolation of Antimicrobial Active Substances from Sophorae Radix

  • 김윤경 (원광대학교 약학대학 한약학과) ;
  • 한완수 (목원대학교 테크노과학대학 생의약화장품학부) ;
  • 정승일 (목원대학교 테크노과학대학 생의약화장품학부) ;
  • 이기남 (원광대학교 한의학전문대학원 제3의학과) ;
  • 김현주 (원광대학교 약학대학 한약학과) ;
  • 이정호 (원광대학교 약학대학 한약학과)
  • Kim, Yun-Gyoung (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Han, Wan-Soo (Division of Biomedicine & Cosmetics, College of Science and Technology) ;
  • Jeong, Seung-Il (Division of Biomedicine & Cosmetics, College of Science and Technology) ;
  • Lee, Ki-Nam (Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Hyun-Ju (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Lee, Jeong-Ho (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University)
  • 발행 : 2005.06.29
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초록

Bioassay-directed fractionation of the dired roots of Sophorae Radix led to the isolation of Sophoraflavanone G. Their structures were elucidated using 1H-NMR, 13C-NMR, UV, IR and mass spectral ananlyses. These compounds exhibited a moderate antimicrobial activities against Streptococcus gordonii, Actinobacillus actinomycetemoomitans and Porphylomonas gingivalis.

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