Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Antioxidant activity of Grewia tiliaefolia bark

  • Published : 2005.03.30
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Abstract

Grewia tiliaefolia is commonly used in India and several other countries for its ethnomedical properties. The antioxidant effect of 50% methanol extract of Grewia tiliaefolia bark was investigated by in-vitro and in-vivo methods. The extract exhibited $IC_{50}$ value of $51.40{\pm}3.98\;{\mu}g/ml$ in DPPH assay. In the in vivo experiments, the treatment was given at 250 and 500 mg/kg body weight doses orally for seven days and catalase, SOD, TBA-RS and ascorbic acid levels were estimated. Both the doses caused a significant increase in the levels of catalase in the liver and kidney, and SOD in the liver, kidney and blood serum. A significant decrease in the level of TBARS was also observed. These results suggest potent antioxidant nature of the extract.

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References

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