Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Toxico-pathological Study p,p-DDE After Experimental Aerosol Exposed to ICR Mouse

환경호르몬인 p,p-DDE의 흡입 시 ICR 마우스의 폐에 미치는 독성병리학적 연구

  • Choi Hae-Yun (College of Oriental Medicine, Daegu Haany University) ;
  • Jung Tae-Young (College of Oriental Medicine, Daegu Haany University) ;
  • Ku Sae-Kwang (Pharmacology & Toxicology Lab., Central Research Laboratories, Dong Wha Pharm. Ind. CO.) ;
  • Yang Hee-Bog (Pharmacology & Toxicology Lab., Central Research Laboratories, Dong Wha Pharm. Ind. CO.) ;
  • Lee Hyeung-Sik (Department of Herbal Biotechnology, Daegu Haany University)
  • 최해윤 (대구한의대학교 한의과대학) ;
  • 정태영 (대구한의대학교 한의과대학) ;
  • 구세광 (동화약품㈜ 중앙연구소 약리독성연구실) ;
  • 양희복 (동화약품㈜ 중앙연구소 약리독성연구실) ;
  • 이형식 (대구한의대학교 한방생명자원공학과)
  • Published : 2005.06.01
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Abstract

In order to monitor the histological and general profiles of lung after direct expose of p,p-DDE, 1, 5 and 10 mg/ml of p,p-DDE were sprayed to male ICR mouse, and seven days after exposure, changes of body weight, lung weight, clinical signs, histological profiles of lung and total WBC in blood were investigated with changes of total cell number and their differential count in bronchoalveolar lavage fluid (BALF). In the present study, a significant and dosage-dependent decrease of body weight was detected in p,p-DDE exposed groups and body weight gains during observational periods (7 days) were also significantly and dosage-dependently decreased in p,p-DDE exposed groups compared to that of vehicle control group. In addition general depression signs were detected in all p,p-DDE exposed groups with dosage-dependent manners, and lung weights were also increased in p,p-DDE exposed groups. Congestion, hemorrhage and severe exudate were observed in the lung of p,p-DDE exposed groups with sarcomatous changes and these signs were also showed by dosage-dependent manners. In addition, foreign body pneumonia signs were observed in the lung of p,p-DDE exposed groups in histological levels. The percentage of ALSA (Area of luminal surface of alveoli) was also significantly and dosage-dependently decreased in p,p-DDE exposed groups and total blood WBC and BALF cell numbers were significantly and dosage-dependently increased in p,p­DDE exposed groups compared to that of vehicle control group and increase percentage of neutrophil, eosinophil, and lymphocyte in BALF were monitored in p,p-DDE exposed groups compared to that of vehicle control group. In conclusion, severe allergic response and/or foreign body pneumonitic changes were induced by direct exposure of p,p-DDE containing beverage. So it is considered that strong and powerful regulation was need to control production of residence of environmental pollutant especially to p,p-DDE.

Keywords

References

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