Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
권호 표지

Effect of Permethrin on Embryonic Developments in Rats

랫드에 미치는 Permethrin의 발생독성에 관한 연구

  • Yoon, Hyo-Jung (Department of Environmental Public Health, School of Public Health, Seoul National University) ;
  • Chung, Moon-Ho (Department of Environmental Public Health, School of Public Health, Seoul National University)
  • 윤효정 (서울대학교 보건대학원 환경보건학과) ;
  • 정문호 (서울대학교 보건대학원 환경보건학과)
  • Published : 2005.08.01
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Abstract

Permethrin, a synthetic pyrethroid insecticide, has been widely used to protect domestic animals and the public health, as well as in agriculture against a variety of pests, which provides potential for environmental exposure. Permethrin is classified as possible human carcinogen and endocrine disrupting chemical by many international authorities. However, its developmental effects have been rarely studied. This study investigated the effects of permethrin during embryo-genesis. Developmental toxicity of permethrin was evaluated using short-term in vitro battery system. Gestation day 9.5 rat embryos (organogenesis) were cultured with permethrin (0.1,0.4 and 0.8 mg/ml) for 48 hours using whole embryo culture system. All the treatments exhibited significant decreases in the total morphological score. Permethrin induced significant growth retardation and the developmental abnormality at doses of 0.4 and 0.8 mg/ml. Moreover, the DNA and protein contents of embryos decreased in dose-dependent manner. These observations suggest that permethrin contributes to toxicity on embryonic developments in rats.

Keywords

References

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