YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Anti-oxidant Effect and Enhancement of Menopausal Signs by Sophorae fructus-derived Isoflavones in Ovariectomized Rats and Cytoprotective Effect in Neuro-2a

난소절제 랫드에서 회화나무 이소플라본의 갱년기증상 개선효과 및 신경세포 보호효과

  • Joo Seong-Soo (College of Pharmacy, Chung-Ang University) ;
  • Won Tae-Joon (College of Pharmacy, Chung-Ang University) ;
  • Lee Yong-Jin (College of Pharmacy, Chung-Ang University) ;
  • Park So-Young (Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University) ;
  • Hwang KwangWoo (College of Pharmacy, Chung-Ang University) ;
  • Lee Do-Ik (College of Pharmacy, Chung-Ang University)
  • Published : 2005.08.01
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Abstract

Isoflavones are reported to playa role in menopausal women as a phytoestrogen, which can replace estradiols in hormone replacement therapy (HRT). Recently; due to the risk of breast cancer by HRT, phytoestrogens (e.g. isoflavones) have been focused as an alternative therapy in menopause. In the study, we investigated whether isoflavones derived from Sophorae fructus (SISO) have more benefit than that of soybean isoflavones in estrogen deficient rats. We found that SISO effectively controled $H_2O_2$ comparing with the baseline (p<0.01 vs. post value of OVX-Cont), and the blood sugar and weight were also controlled with decreasing patterns. Additionally, in LDH assay for cytoprotective effect in Neuro-2a cell line, SISO protected cells from the damage by SNAP (p<0.05). In conclusion, SISO may have more beneficial effect in enhancing the menopausal signs than that of soybean isoflavones and the cytoprotective effect in neuron cells suggests that SISO can play a certain role in neuroprotection after menopause.

Keywords

References

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