Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

HISTOLOGICAL CHANGES AND EXPRESSION OF NERVE GROWTH FACTOR IN THE INFERIOR ALVEOLAR NERVE AFTER DISTRACTION OSTEOGENESIS

하악골 신장술 후 하치조신경의 조직학적 변화와 신경성장인자의 발현에 대한 연구

  • Park, Bong-Wook (Department of Oral & Maxillofacial Surgery, College of Medicine, Gyeongsang National University) ;
  • Kim, Jong-Ryoul (Department of Oral & Maxillofacial Surgery, College of Dentistry, Pusan National University) ;
  • Byun, June-Ho (Department of Oral & Maxillofacial Surgery, College of Medicine, Gyeongsang National University)
  • 박봉욱 (경상대학교 의과대학 치과학교실 구강악안면외과) ;
  • 김종렬 (부산대학교 치과대학 구강악안면외과학교실) ;
  • 변준호 (경상대학교 의과대학 치과학교실 구강악안면외과)
  • Published : 2005.09.30
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Abstract

Distraction osteogenesis (DO) is frequently used technique in reconstruction of bony defects resulted from tumor resection, congenital deformity, and trauma in the maxillofacial region. Although the histologic and ultrastructural changes associated with distraction osteogenesis have been extensively described, the exact changing of the surrounding tissues, such as nerve tissues, were still unclear. This study observed the histological changes and the expression of nerve growth factor (NGF) in the inferior alveolar nerve (IAN) after distraction osteogenesis. Unilateral mandibular distraction (0.5 mm twice per day for 10 days) was performed in eight mongrel dogs. Two animals were sacrificed at 7, 14, 28 and 56 days after completion of distraction, respectively. The distracted IAN and contralateral control nerve were harvested and processed for histological and innunohistochemical examinations. The signs of acute nerve injuries, such as demyelination and partial discontinuation of nerver fiber, were observed in the distracted IAN on 7 and 14 days after distraction. The initial remyelination and regeneration of distracted IAN were showed at 14 days after completion of distraction. At 56 days later, the histologic features of distracted IAN was similar to those of the normal control IAN. The expression of NGF was significantly increased in most distracted nerve tissues on 7, 14 and 28 days after distraction. On 56 days after distraction, the expression of NGF returned to the normal level. This study suggested that the acute IAN injury caused by mandibular distraction were mostly recovered during consolidation period. The NGF was seemed to be induced from Schwann cell and damaged nerve tissues, and it may have important roles in the initial healing of damaged nerves.

Keywords

References

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