KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Technological Trend of Crystallization Research for Bioproduct Separation

Bioproduct 분리를 위한 결정화 연구 동향

  • Kim, Woo-Sik (Department of Chemical Engineering, Kyunghee University) ;
  • Lee, Eun-Kyu (Department of Chemical Engineering, Hanyang University)
  • Published : 2005.06.01
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Abstract

In bioengineering field, current academic trends and informations on crystallization technology for bioproduct separation were summarized. It is essential for utilizing the crystallization technology to understand the fundamental phenomena of crystallization of crystal nucleation, crystal growth, crystal agglomeration and population balance for the design of crystallizers. In general, the crystal nucleation that the crystalline solids occur from the solution is analyzed by Gibb's free energy change in the aspect of thermodynamics and in the present paper the crystal nucleation models based on the above thermodynamics are summarized by their key characteristics. The crystal growth and agglomeration, which have been studied over 50 years and are essential phenomena for separation technology, are reviewed from their basic concept to most leading edge trend of researches. In the material and population balances for the designs of crystallization separation process, the analysis of crystallizers is summarized. Thereon, the present review paper will academically contribute the understanding the crystallization phenomena and the design of the crystallization separation process.

Keywords

References

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