YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effect of NMDA Receptor on Analgesic Effect of Bovine Milk-derived Lactoferrin (BLF)

우유속 락토페린의 NMDA 수용체를 통한 진통효과

  • Jeon, Yong-Joon (Pharmacological Research Department, National Institute of Toxicological Research) ;
  • Yun, Jae-Suk (Pharmacological Research Department, National Institute of Toxicological Research) ;
  • Lim, Hwa-Kyung (Pharmacological Research Department, National Institute of Toxicological Research) ;
  • Park, Ki-Suk (Pharmacological Research Department, National Institute of Toxicological Research) ;
  • Na, Han-Kang (Pharmacological Research Department, National Institute of Toxicological Research) ;
  • Kim, Dong-Sup (Pharmacological Research Department, National Institute of Toxicological Research) ;
  • Kim, Joo-il (Pharmacological Research Department, National Institute of Toxicological Research) ;
  • Yoon, Yea-Chang (Department of Dairy Science Graduate School of Kon-kuk University) ;
  • Choi, Ki Hwan (Pharmacological Research Department, National Institute of Toxicological Research)
  • 전용준 (국립독성연구원 약리연구부) ;
  • 윤재석 (국립독성연구원 약리연구부) ;
  • 임화경 (국립독성연구원 약리연구부) ;
  • 박기숙 (국립독성연구원 약리연구부) ;
  • 나한광 (국립독성연구원 약리연구부) ;
  • 김동섭 (국립독성연구원 약리연구부) ;
  • 김주일 (국립독성연구원 약리연구부) ;
  • 윤여창 (건국대학교 자연대학) ;
  • 최기환 (국립독성연구원 약리연구부)
  • Published : 2005.10.01
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Abstract

Lactoferrin is a multifunctional protein that is found in milk, neutrophils, and other biological fluids, and its receptors have also been identified in the central nervous system. Recently, it was reported that bovine milk-derived lacto­ferrin (BLF) produced analgesia via a $\mu$-opioid receptor-mediated response in the spinal cord. However the precise mech­anism of this analgesic effect is remains unclear. In Randall-Selitto paw pressure study, each single administration of morphine (10 mg/kg) and BLF (50, 100 and 200 mg/kg) induced analgesia, however, NMDA receptor antagonist MK-801 (0.1, 0.2 and 0.3 mg/kg), inhibited analgesia induced by BLF (100 mg/kg). Intracerebroventricular infusion (I.C.V.) of N­methyl-D-aspartic acid (NMDA) ($0.3\;{\mu}g/8.0\;{\mu}l/hr/day$), as a NMDA receptor agonist, reversed inhibition of MK-801 (0.3 mg/kg) on analgesia induced by BLF (100 mg/kg). These results suggest that BLF have analgesic effect, through NMDA recep­tor activation.

Keywords

References

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