YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Anxiolytic-like Effects of Phenylpropanoids Using the Elevated Plus-Maze in Mice

Elevated Plus-maze를 이용한 Phenylpropanoid의 항불안 효과

  • Yoon, Byung Hoon (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Choi, Ji Woong (Department of Pharmacology, College of Pharmacy, Seoul National University) ;
  • Jung, Ji Wook (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Shin, Jin Sun (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Hyeon, Seong Ye (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Cheong, Jae Hoon (Department of Pharmacy, Sahmyook University) ;
  • Ryu, Jong Hoon (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Ko, Kwang Hee (Department of Pharmacology, College of Pharmacy, Seoul National University)
  • Published : 2005.10.01
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Abstract

The purpose of this study was to characterize the putative anxiolytic-like effects of phenylpropanoids using the elevated plus maze (EPM) test in mice. Cinnamic acid, p-coumaric acid, caffeic acid and ferulic acid were orally administered to male ICR mice, 1 h before behavioral evaluation in an EPM, respectively. Control mice were treated with an equal volume of vehicle, and positive control mice diazepam (1 mg/kg). A single treatment with phenylpropanoids (at 8 mg/kg) significantly increased time-spent and arm entries into the open arms of the EPM, and decreased time-spent and arm entries into the closed arms of the EPM versus control (P<0.05). However, no changes in the locomotor activity and myorelaxant effect were seen in any group versus the saline control. These results suggest that phenylpropanoids may be an effective anx-iolytic agent.

Keywords

References

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