Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Synthesis of New Triazolyl-N,N-Dialkyldithiocarbamates as Antifungal Agents

  • Ozkirimli Sumru (Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry) ;
  • Apak T. Idil (Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry) ;
  • Kiraz Muammer (Istanbul University, Istanbul Faculty of Medicine, Microbiology and Clinical Microbiology Department) ;
  • Yegenoglu Yildiz (Istanbul University, Istanbul Faculty of Medicine, Microbiology and Clinical Microbiology Department)
  • Published : 2005.11.01
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Abstract

N,N-Dialkylditihiocarbamate derivatives have been well known as broad-range fungicides. In this study, the triazole derivatives of ten new N,N-disubstituted dithiocarbamates (3a-j) were synthesized and their structures were identified by spectral and elemental analysis. Results of the antifungal activity studies showed that some of the compounds tested were active against M. canis, M. gypseum, and T rubrum at the concentration of 12.5 $\mu$g/mL when c1otrimazol was used as a standard.

Keywords

References

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