Archives of Pharmacal Research

  • 제28권11호
  • /
  • Pages.1228-1232
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  • 2005
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Antibacterial and Antitumor Macrolides from Streptomyces sp. Is9131

  • Zhao Pei-Ji (The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science) ;
  • Fan Li-Ming (The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science) ;
  • Li Guo-Hong (Laboratory for Conservation and Utilization of Bio-resource, Yunnan University) ;
  • Zhu Na (The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science) ;
  • Shen Yue-Mao (The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science)
  • 발행 : 2005.11.01
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초록

Four compounds, including two novel macrolides, were isolated from an endophyte Streptomyces sp. Is9131 of Maytenus hookeri. Spectral data indicated that these compounds were dimeric dinactin (1), dimeric nonactin (2), cyclo-homononactic acid (3), and cyclo-nonactic acid (4). Bioassay results showed that dimeric dinactin had strong antineoplastic activity and antibacterial activity.

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참고문헌

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