Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Evaluation of the Estrogenic Activity of Isoflavones from the Rhizome of Belamcanda chinensis

  • Yoo, Hye-Hyun (College of Pharmacy, Seoul National University) ;
  • Jin, Yong-Ri (Affiliated Hospital, College of Medicine, Yanbian University) ;
  • Jin, Jing-Ling (Natural Products Research Institute, Seoul National University) ;
  • Lee, Sang-Hyun (College of Pharmacy, Seoul National University)
  • Published : 2005.02.28
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Abstract

Four compounds were isolated from the rhizome of Belamcanda chinensis (Iridaceae) by repeated column chromatography and were elucidated as iristectorigenin A, irigenin, tectorigenin and tectoridin by spectral analysis. The estrogenic activity of these isoflavones was tested using Ishikawa cells. Irigenin, tectorigenin and tectoridin were highly estrogenic ($EC_{50}\;=\;0.75$, 0.42 and $0.81\;{\mu}g/ml$, respectively), while iristectorigenin A exhibited weak estrogenic activity ($EC_{50}{\geq}4\;{\mu}g/ml$).

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