Comparative Study of Red Wine and Korean Black Raspberry Wine in Adipocyte Differentiation and Cardiovascular Disease Related Gene Expression

  • Choi, Hyuek (Department of Animal Science, Chonnam National University) ;
  • Myung, Kyu-Ho (Department of Animal Science, Chonnam National University)
  • Published : 2005.08.30

Abstract

Abilities of Korean black raspberry (KBR) wine to induce differentiation of 3T3 L1 adipocytes and express HepG2 cardiovascular disease-related genes were determined and compared with those of red wine. Red wine attenuated the differentiation of adipocytes faster than KBR wine and control. KBR wine decreased cholesterol concentration in HepG2 cells at a similar level to that of red wine, resulting in similar degrees of suppression in apolipoprotein B100, and enhancement in LDL receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels.

Keywords

References

  1. Lancet v.344 Wine, alcohol, platelets, and the French paradox for coronary heart disease Renaud, S.
  2. J. Nutr. v.133 Red wine pholiphenolics increase LDL receptor expression and activity and suppress the secretion of ApoB 100 from human HepG2 cells Pal, S.;Ho, N.;Santos, C.;Dubois, P.;Mamo, J.;Croft, K.;Allister, E.
  3. Free Radical Biol. Med. v.20 Structure-antioxidant activity relationships of flavonoid and phenolic acids Rice-Evans, C.A.;Miller, N.J.;Paganga, G.
  4. J. Agr. Food Chem. v.52 Inhibition of protein and lipid oxidation in liposmes by berry phenolics Viljanen, K.;Kylli, P.;Kivikari, R.;Heinonen, M.
  5. Food Sci. Biotechnol. v.13 Antioxidant actiivity of triticale caryopses and embryos extracts Karamac, M.;Amarowicz, R.;Weidner, S.;Abe, S.;Shahidi, F.
  6. Food Sci. Biotechnol. v.14 Antioxidant activities of colored sweet potato cultivars by plant parts Boo, H.O.;Chon, S.M.;Kim, S.M.;Pyo, B.S.
  7. Obes. Res. v.5 CCAAT/enhancer-binding protein ${\beta}$ cannot overcome TCDD inhibition of 3T3-L1 preadipocyte differentiation Chen, C.;Brodle, A.E.;Hu, C.Y.
  8. Anal. Biochem. v.162 Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction Chomozynski, P.;Sacchi, N.
  9. Nature v.227 Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Laemili, U.K.
  10. Semin. Cell Dev. Bio. v.10 Molecular regulation of adipocyte differentiation Cowherd, R.M.;Lyle, R.E.;McGehee, R.E. Jr.
  11. Aterio. Thrombo. Vascular Bio. v.18 Effect of atorvastin on intracellular stability and secretion of apolipoprotein B in HepG2 cells Mohammadi, A.;Marci, J.;Newton, R.;Romain, T.;Dulay, D.;Adeli, K.
  12. Science v.232 Receptor-mediated pathway for cholesterol homeostasis Brown, M.S.;Goldstein, J.L.A.