Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Antioxidant Effects of Isoflavones from the Stem Bark of Cudrania tricuspidata

  • Lee, Jin-Hwan (Division of Applied Life Science (BK21 program), Institute of Agricultural & Life Sciences, Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Lee, Byong-Won (Division of Applied Life Science (BK21 program), Institute of Agricultural & Life Sciences, Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Kim, Jin-Hyo (Division of Applied Life Science (BK21 program), Institute of Agricultural & Life Sciences, Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Seo, Woo-Duck (Division of Applied Life Science (BK21 program), Institute of Agricultural & Life Sciences, Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Jang, Ki-Chang (Division of Applied Life Science (BK21 program), Institute of Agricultural & Life Sciences, Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Park, Ki-Hun (Division of Applied Life Science (BK21 program), Institute of Agricultural & Life Sciences, Department of Agricultural Chemistry, Gyeongsang National University)
  • Published : 2005.12.31
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Abstract

Isoflavones 4'-O-methylalpinumisoflavone (1) and 5, 7, 4'-trihydroxy-6,8-diprenylisoflavone (2) were isolated from stem bark of Cudrania tricuspidata (Carr.) Bureau. These compounds were the first reported from this plant. Antioxidant activities 1 and 2 were evaluated by measuring their ability to scavenge DPPH and ABTS radicals. Diprenylisoflavone 2 showed strong scavenging activity against ABTS ($IC_{50}\;=\;16.3\;{\mu}M$), three-fold higher compared to genistein, which do not possess prenylated group which indicates strong scavenging activity against ABTS radical of isoflavone 2 was due to prenyl group.

Keywords

References

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