Asian-Australasian Journal of Animal Sciences

  • 제18권2호
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  • Pages.165-169
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  • 2005
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Association of Candidate Genes with Production Traits in Korean Dairy Proven and Young Bulls

  • Jang, G.W. (Animal Genomics & Bioinformatics Division, National Livestock Research Institute) ;
  • Cho, K.H. (Animal Genomics & Bioinformatics Division, National Livestock Research Institute) ;
  • Kim, T.H. (Animal Genomics & Bioinformatics Division, National Livestock Research Institute) ;
  • Oh, S.J. (Animal Genomics & Bioinformatics Division, National Livestock Research Institute) ;
  • Cheong, I.C. (Animal Genomics & Bioinformatics Division, National Livestock Research Institute) ;
  • Lee, K.J. (Animal Genomics & Bioinformatics Division, National Livestock Research Institute)
  • 투고 : 2004.05.05
  • 심사 : 2004.10.16
  • 발행 : 2005.02.01
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초록

This study was performed to offer effective basic data for selection and improvement of Korean dairy cattle through identifying distributional properties among candidate genes (bovine butyrophilin, signal transducers and activators of transcription 5a, and prolactin hormone). In this study, polymorphisms of candidate genes were identified and the relationships between loci and production traits of each gene were analyzed using frozen semen of Holstein bulls (19 proven and 77 candidates). In butyrophilin (BTN) locus, polymorphisms information contents (PIC) value of BTN2 (0.372) was higher than those of others (BTN1; 0.155, BTN3; 0.254, BTN4; 0.169). As a result of analysis of genotyping STAT5a, using single stranded conformational polymorphism (SSCP) method and microsatellite locus, PIC values were 0.189 and 0.457, respectively. And PIC value of prolactin hormone gene was 0.176. In the relationships between genotypes and production traits, BTN3 was associated with 305-day production traits (p<0.05). PTAs for B allele were such as 110.43, 88.28 and 75.25 in BTN1, 3, 4 and these values were higher than those of A allele, but in the case of BTN2, A allele with 154.19 was higher than that of B allele. The results obtained from using candidate genes may be used as an useful index for the genetic improvement of dairy cattle population in Korea, and further studies are needed.

키워드

참고문헌

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피인용 문헌

  1. Novel SNPs of butyrophilin (BTN1A1) and milk fat globule epidermal growth factor (EGF) 8 (MFG-E8) are associated with milk traits in dairy goat vol.38, pp.1, 2011, https://doi.org/10.1007/s11033-010-0118-y
  2. Analysis of Genetic Variation at the Prolactin-RsaI (PRL-RsaI) Locus in Indian Native Cattle Breeds (Bos indicus) vol.49, pp.1-2, 2011, https://doi.org/10.1007/s10528-010-9383-7