Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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Effect of Epidermal Growth Factor on Full Thickness Skin Defects of the Inoperable Patients

수술적 치료가 불가능한 환자의 전층 피부결손에 대한 표피성장인자의 유용성

  • Lee, Jong Hoon (Department of Plastic and Reconstructive Surgery, Eulji University College of Medicine) ;
  • Lee, Young Jong (Department of Plastic and Reconstructive Surgery, Eulji University College of Medicine) ;
  • Hong, Sung Hee (Department of Plastic and Reconstructive Surgery, Eulji University College of Medicine) ;
  • Kim, Jun Pyo (Department of Plastic and Reconstructive Surgery, Eulji University College of Medicine)
  • 이종훈 (을지대학교 의과대학 성형외과학교실) ;
  • 이영종 (을지대학교 의과대학 성형외과학교실) ;
  • 홍성희 (을지대학교 의과대학 성형외과학교실) ;
  • 김준표 (을지대학교 의과대학 성형외과학교실)
  • Received : 2004.12.23
  • Published : 2005.05.10
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Abstract

For treatment of full thickness skin defects caused by trauma or infections, skin grafts or flaps have been the treatment of choice to date. However, in patients who are not candidates for surgery, either due to his general conditions or refusal to receive treatment, supportive methods have been the only means of care, which inherently caused psychological trauma to the patient due to uncertainties of ultimate outcome and the length of treatment. This study aimed to heal full thickness skin defects through application of topical epidermal growth factor in patients who have received 2 to 3 weeks of conservative management using medifoam $B^{(R)}$ without improvement. Six patients from March 2002 to July 2004 were enrolled. The mean size of defects was $5.4{\times}4.6cm$ in 4 patients with carcinoma and $6.4{\times}4.1cm$ in 2 patients with osmidrosis. Commercially available 0.005% EGFR solution was used, and dressing was performed once daily. All patients benefitted from the use of EGF, with closure of skin defects taking an average of 28 days in cancer patients and 22.5 days in osmidrosis cases. EGF can be used as a supportive mean of treatment in the inoperable patients with skin defects, with resultant hastening of healing shortening duration of treatment.

Keywords

References

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