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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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The Association between the T102C Polymorphism of the HTR2A Serotonin Receptor Gene and HDL Cholesterol Level in Koreans

  • Choi, Jin-Ho (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Zhang, Shu-Ying (Clinical Research Institute, Seoul National University Hospital) ;
  • Park, Kyung-Woo (Clinical Research Institute, Seoul National University Hospital) ;
  • Cho, Young-Seok (Clinical Research Institute, Seoul National University Hospital) ;
  • Oh, Byung-Hee (Clinical Research Institute, Seoul National University Hospital) ;
  • Lee, Myoung-Mook (Clinical Research Institute, Seoul National University Hospital) ;
  • Park, Young-Bae (Clinical Research Institute, Seoul National University Hospital) ;
  • Kim, Hyo-Soo (Clinical Research Institute, Seoul National University Hospital)
  • Published : 2005.03.31
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Abstract

5-HT2A is one of major serotonin receptor that is involved in the action of serotonin-targeting drugs. Previous clinical studies have shown an unexpected association between lower cholesterol level and psychiatric diseases, in which T102C polymorphism of HTR2A, gene of 5-HT2A serotonin receptor, might be involved. Therefore, we hypothesized a potential association between lower cholesterol level and T102C polymorphism. The effect of the T102C polymorphism on the serum lipid profiles of 646 subjects without specific psychiatric disease was investigated. Genotype was determined by polymerase chain reaction and restriction fragment length polymorphism analysis. There were significantly lower levels of total cholesterol ($193.6{\pm}35.0$ versus $202.1{\pm}45.5\;mg/dl$, p = 0.016) and HDL-cholesterol ($42.7{\pm}11.6$ versus $46.3{\pm}12.7\;mg/dl$, p = 0.004) in CC genotype than non-CC genotypes. Moreover, multivariate analysis showed that the CC genotype is a strong predictor of a lower HDL-cholesterol level (p < 0.001). In conclusion, this study shows that the CC genotype of the HTR2A gene is related to lower HDL-cholesterol level in Koreans. This is the first demonstration showing the potential genetic relationship between the serotonin receptor gene polymorphism and the HDL-cholesterol level.

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References

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