Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Effects of Fluoride Levels on Lipid Peroxidation and Antioxidant Systems of Growing/Finishing Pigs

  • Tao, X. (Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Feed Science Institute Zhejiang University) ;
  • Xu, Z.R. (Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Feed Science Institute Zhejiang University) ;
  • Han, X.Y. (Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Feed Science Institute Zhejiang University) ;
  • Wang, Y.Z. (Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Feed Science Institute Zhejiang University) ;
  • Zhou, L.H. (Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Feed Science Institute Zhejiang University)
  • Received : 2004.06.17
  • Accepted : 2004.12.04
  • Published : 2005.04.01
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Abstract

Malondialdehyde (MDA) and total antioxidant capacity (T-AOC) levels, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), glutathione transferase (GST) and xanthine oxidase (XOD) activities were analyzed in serum, livers and kidneys of pigs treated with graded doses of fluoride (as NaF). Ninety-six Duroc-Landrace-Yorkshire crossbred growing pigs (48 barrows and 48 gilts, respectively), with similar initial weight 24.14${\pm}$1.12kg, were randomly assigned to four different treatments. These treatments containing the following added F: basal control; 50 mg/kg F; 100 mg/kg F and 150 mg/kg F were randomly assigned to four pens (three barrows and three gilts) each in a completely randomized design. The results showed pigs treated with 150 mg/kg F significantly decreased average daily gain (ADG) (p<0.05) and increased feed/gain ratio (F/G) (p<0.05) compared to the controls. In the groups treated with fluoride, the contents of MDA increased, T-AOC levels and the activities of SOD, GSH-PX, CAT, GST and XOD decreased, and most of which altered significantly (p<0.05). The study therefore indicated the mechanism of excess fluoride on the impairment of soft tissues involved in lipid peroxidation and decreased the activities of some enzymes associated with free radical metabolism.

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