Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
권호 표지

Clinical Outcomes of Frozen-thawed Embryo Transfer after Microsurgical Removal of Damaged Blastomere

동결-융해 배아 이식에서 손상된 할구의 미세 수술적 제거의 임상적 효과

  • Choi, Won Yun (Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University) ;
  • Sohn, Jie Ohn (Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University) ;
  • Park, Eun A (Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University) ;
  • Lee, Dong Ryul (Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University) ;
  • Lee, Woo Sik (Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University) ;
  • Han, Se Yul (Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University) ;
  • Park, Lee Suk (Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University) ;
  • Cho, Jung Hyun (Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University) ;
  • Kim, Soo Hee (Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University) ;
  • Cha, Kwang Yul (Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University) ;
  • Yoon, Tae Ki (Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University)
  • 최원윤 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 손지온 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 박은아 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 이동률 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 이우식 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 한세열 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 박이석 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 조정현 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 김수희 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 차광렬 (포천중문의과대학교 차병원 여성의학연구소) ;
  • 윤태기 (포천중문의과대학교 차병원 여성의학연구소)
  • Published : 2005.03.30
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Abstract

Objective: Human infertility clinics have been faced the demand for improving clinical results. The purpose of this study was to evaluate the effect of microsurgical removal of damaged blastomeres (DB) in frozen-thawed embryos on the clinical outcomes. Methods: From January 2003 to May 2004, out of 258 thawing ET cycles were divided into three groups: Group-1 (n=46): Intact cleavaged embryos after thawing. Remained cycles with embryos containing DB were randomly divided into two groups. Group-2 (n=102): Drilling zona pellucida (ZP) of frozen-thawed embryos by acidified Tyrode's solution. Group-3 (n=110): Drilling ZP and removal of DB. Embryos after microsurgical manipulation were transferred into the uterus of patients. Results: Clinical profiles and the mean number of transferred embryos among three groups were not different. Pregnancy and implantation rates were similar in three groups. It were 30.4% and 9.3% in Group-1, 29.4% and 7.8% in Group-2, and 26.4% and 7.6% in group-3, respectively. Miscarriage rate in Group-3 (37.9%) was slightly higher than those in Group-1 and Group-2 (14.3% and 23.3%), but it was not statistically significant. Conclusion: Intact cleaving embryos after DB removal showed higher potent of pregnancy and implantation. We could not find any improvement of clinical outcome by removal of DB in frozen-thawed embryos.

Keywords

Acknowledgement

Supported by : 세로노 코리아

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