Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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The Effect of Isoflavone Supplementation on Plasma Biochemical Parameters of Women with Polycystic Ovary Syndrome

다낭성 난소 증후군 환자에서 Isoflavone 섭취에 따른 혈중 생화학적 지표의 변화

  • Won, Hyung Jae (Department of Obstetrics and Gynecology, Yong dong Severance Hospital, Yonsei University) ;
  • Kang, Ju Hee (Department of Food and Nutrition, The graduate School of Yonsei University) ;
  • Lee, Min Jun (Department of Food and Nutrition, The graduate School of Yonsei University) ;
  • Yoon, Sun (Department of Food and Nutrition, The graduate School of Yonsei University) ;
  • Park, Ki Hyun (Department of Obstetrics and Gynecology, Yong dong Severance Hospital, Yonsei University) ;
  • Cho, Dong Je (Department of Obstetrics and Gynecology, Yong dong Severance Hospital, Yonsei University) ;
  • Song, Chan Ho (Department of Obstetrics and Gynecology, Yong dong Severance Hospital, Yonsei University) ;
  • Lee, Byung Seok (Department of Obstetrics and Gynecology, Yong dong Severance Hospital, Yonsei University)
  • 원형재 (연세대학교 의과대학 영동세브란스병원 산부인과학교실) ;
  • 강주희 (연세대학교 생활과학대학 식품영양학과) ;
  • 이민준 (연세대학교 생활과학대학 식품영양학과) ;
  • 윤선 (연세대학교 생활과학대학 식품영양학과) ;
  • 박기현 (연세대학교 의과대학 영동세브란스병원 산부인과학교실) ;
  • 조동제 (연세대학교 의과대학 영동세브란스병원 산부인과학교실) ;
  • 송찬호 (연세대학교 의과대학 영동세브란스병원 산부인과학교실) ;
  • 이병석 (연세대학교 의과대학 영동세브란스병원 산부인과학교실)
  • Published : 2005.03.30
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Abstract

Objective: This study was performed to evaluate the effect of isoflavone supplementation on hormone levels, lipid profiles and total antioxidant status in patients with polycystic ovary syndrome. Methods: Total 11 women with polycystic ovary syndrome were supplemented daily with 150mg of isoflavone for 6 months. Blood samples were collected 0, 3, and 6 months after supplement of isoflavone for analysis of LH, FSH, E2, testosterone, free testosterone, SHBG levels, serum lipid profiles, and total antioxidant status (TAS). Results: After 6 months isoflavone supplementation, the hormone levels did not change significantly. Serum lipid profiles did not show any significant change in total cholesterol, LDL-cholesterol, triglyceride, lipoprotein(a), and free fatty acid levels. However, there was significant increase in HDL-cholesterol (p<0.05) for 3 months. Total antioxidant status was increased significantly after isoflavone supplementation for 6 months (p<0.05). Conclusion: Isoflavone supplementation showed positive effects on the HDL-cholesterol and total antioxidant status. it is implicated that isoflavone supplementation will may have a effect on cardiovascular disease in patients with polycystic ovary syndrome.

Keywords

Acknowledgement

Supported by : (주)태평양

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