Systemic Aspergillosis associated with bovine viral diarrhea virus infection in Korean native calves

한우송아지의 BVD바이러스 감염과 Aspergillus fumigatus의 복합감염

  • Jean, Young Hwa (National Veterinary Research & Quarantine Service) ;
  • Kim, Jae Hoon (Department of Veterinary Medicine, Jeju National University) ;
  • Kim, Dae Yong (College of Veterinary Medicine, Seoul National University) ;
  • Jeong, Soon Wuk (College of Veterinary Medicine, Konkuk University) ;
  • Moon, Oun Kyong (National Veterinary Research & Quarantine Service) ;
  • Cho, Doo Youn (Department of Veterinary Pathology, Louisiana State University)
  • Accepted : 2004.12.09
  • Published : 2005.03.25

Abstract

Systemic aspergillosis were outbroken of 17 Korean native calves at livestock farm in Kyunggi province. Two 3 months old calves were died after having diarrhea, coughing, dyspnea, nasal discharge, and abdominal breathing. These calves were diagnosed of aspergillosis as multifocal to coalescing pyogranulomatous inflammation with intralesional aspergillus infiltration at liver, kidney, spleen, heart, lymph nodes, lungs, intestine and cerebrum. Aspergillus fumigatus was cultured from the affected tissues. And the small intestine was positive against bovine viral diarrhea (BVD) virus on FA test. We considered that the secondary fungal infections killed the calves after BVD virus infection primarily.

Keywords

References

  1. Chihaya Y, Matsukawa K, Ohshima K, Matsui Y, Ogasa K, Furusawa Y, Okada H. A pathological study of bovine alimentary mycosis. J Comp Pathol 1992, 107, 195-206 https://doi.org/10.1016/0021-9975(92)90036-T
  2. High KP, Washburn RG. Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (Rapamycin). J Infect Dis 1997, 175, 222-225 https://doi.org/10.1093/infdis/175.1.222
  3. Jean YH, Hwang EI, Kim JM, Kwon YB, Chung UI, Youn CK. Disseminated Aspergillus fumigatus infection in Korean calf. Res Rept RDA(V), 1988, 30, 22-27
  4. Jensen HE, Olsen, SN, Aalbaek B. Gastrointestinal aspergillosis and zygomycosis of cattle. Vet Pathol 1994, 31, 28-36 https://doi.org/10.1177/030098589403100104
  5. Jensen HE, Schonheyder H, Basse A. Acute disseminated aspergillosis in a cow with special reference to penetration and spread. J Comp Pathol 1991, 104, 411-417 https://doi.org/10.1016/S0021-9975(08)80151-X
  6. Jubb KVF, Kennedy PC, Palmer N. Pathology of Domestic Animals, Vol. 2. pp. 156-157, 4th ed. Academic Press, California, 1993
  7. Radostits OM, Gay CC, Blood DC, Hinchcliff KW. Veterinary Medicine. pp. 1085-1105, 1279-1281, 9th ed. Saunders, London, 2000
  8. Rhodes JC, Jensen HE, Nilius AM, Vhitambar CR, Farmer SG, Washburn RG, Steele PE, Amlung TW. Aspergillus and aspergillosis. J Med Vet Mycol 1992, 30, 51-57
  9. Schoder G, Mostl K, Benetka V, Baumgartner W. Different outcome of intrautrine infection with bovine viral diarrhea(BVD) virus in twin calves. Vet Rec 2004, 154, 52-53 https://doi.org/10.1136/vr.154.2.52
  10. Shahriar FM, Clark EG, Janzen E, West K, Wobeser G. Coinfection with bovine viral diarrhea virus and mycoplasma bovis in feedrot cattle with chronic pneumonia. Can Vet J 2002, 43, 863-868