Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Risk Assessment of Human Exposure to Methidathion during Harvest of Cucumber in Green House

  • Byoun Ji-Youn (School of Agricultural Biotechnology, Seoul National University) ;
  • Choi Hoon (School of Agricultural Biotechnology, Seoul National University) ;
  • Moon Joon-Kwan (School of Agricultural Biotechnology, Seoul National University) ;
  • Park Hee-Won (School of Agricultural Biotechnology, Seoul National University) ;
  • Liu Kwang-Hyeon (Department of Pharmacology and Pharmaceo Genomics Research Center, Inje University College of Medicine) ;
  • Ihm Yang-Bin (Department of Crop Life Safety, Natural Institute of Agricultural Science and Technology, Rural Development Administration) ;
  • Park Byeoung-Soo (School of Agricultural Biotechnology, Seoul National University) ;
  • Kim Jeong-Han (School of Agricultural Biotechnology, Seoul National University)
  • Published : 2005.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

Farmers are generally expressed to pesticides through mixing loding, application activity and harvesting of crop after application of pesticides. The present work investigated the exposure and risk of furathiocarb to workers when harvesting of cucumber was carried out in green house after application of furathiocarb EC. Glove was used for the hand exposure assessment, socks for foot and dermal patches for the other parts of body. Personal air monitor equipped with a XAD-2 resin was used for the respiratory exposure assessment. During the harvest of cucumber in green house, the initial rate of potential dermal exposure (Day 1) for methidathion was 1.3 mg/hr. The major exposure parts were hand $(78\~83\%),\;thigh\;(5\~7\%)$ and arms $(6\~9\%)$ during 3 days' harvest. No exposure was detected from the respiratory monitoring. For risk assessment, the potential dermal exposure (PDE), the absorbable quantity of exposure (AQE) and the margin of safety (MOS) and margin of exposure (MOE) were calculated. In risk assessment of harvester exposure for 7days, all MOS was > 1 and MOE was > 100 indicating that possibility of risk was little.

Keywords

References

  1. Calumpang, S.M.F. (1996): Exposure of four filipino farmers to parathion-methyl while spraying string beans. Pesticide Science, 46, 93-102 https://doi.org/10.1002/(SICI)1096-9063(199601)46:1<93::AID-PS324>3.0.CO;2-M
  2. Choi, H., Moon, J.K., Liu, K.H., Park, H.W., Ihm, Y.B., Park, B.S. and Kim, J.H. (2005): Ristk Assessment of Human Exposure to Cypermethrin During Treatment of Mandarin Fields. In press Archives of Environmental Contamination and Toxicology https://doi.org/10.1007/s00244-005-1050-3
  3. Durham, W.F. and Wolfe, H.R. (1962): Measurement of the exposure of workers to pesticides. Bulletin of World Health Organization, 26, 75-91
  4. Feldman, R.J. and Maibach, H.I. (1974): Percutaneous penetration of some pesticides and herblcices in man. ToxIcology and Applied Pharmacology, 28, 126-132 https://doi.org/10.1016/0041-008X(74)90137-9
  5. Fenske, R.A. and Elkner, K.P. (1990): Multi-route exposure assessment and biological monitoring of urban pesticide applicators during structural control treatments with chlorpyrifos. Toxicology and Industrial Health, 6, 349-371 https://doi.org/10.1177/074823379000600301
  6. Jensen, J.K. (1984): The assumptions used for exposure assessments. In: Siewierski, M. (ed.) Determination and assessment of pesticide exposure. Elsevier, New York, 147-152
  7. Krieger, R.I., Bernard, C.E., Dinoff, T.M., Fell, L., Osimitz, T.G., Ross, J.H. and Thongsinthusak, T. (2000): Biomonitoring and whole body cotton dosimetry to estimate potential human dermal exposure to semivolatile chemicals. Journal of Exposure Analysis and Environmental Epidemiology, 10, 50-57 https://doi.org/10.1038/sj.jea.7500072
  8. Kieczka, H. (1993): Requirements for safe-quarding the health of applicators of plant protection products - an overview. In: Second International Symposium on Pesticides Application Techniques, Strasbourg, Annals, n. 2/2. BCPC, Strasbourg, pp. 455-462
  9. Keith, L.H. 1998. Environmental endocrine disruptors. John Wiley & Sons, New York
  10. Liu, K.H., Kim, C.S. and Kim, J.H. (2003): Human exposure assessment to mancozeb during treatment of mandarin fields. Bulletin of Enviromental Contamination and Toxicology, 70, 336-342 https://doi.org/10.1007/s00128-002-0196-1
  11. Liu, K.H., Byoun, J.Y., Sung, H.J., Lee, H.K., Kim, K., Lee, H.S. and Kim, J.H. (2001): Simultaneous determination of furathiocarb and metabolites in biological tissues by high-performance liquid chromatography and post-column derivatization. Chromatographia, 53, 687-690 https://doi.org/10.1007/BF02493021
  12. Machado-Neto, J.G. (2001): Determination of safe work time and exposure control need for pesticide applicators. Bulletin of Environmental Contamination and Toxicology, 67, 20-26 https://doi.org/10.1007/s001280086
  13. Predictive Operator Exposure Model (POEM) (1992). A user guide, Pesticide Safety Directorate, UK
  14. Renwick, A.G. (2000): The use of safety or uncertainty factors in the setting of acute reference doses. Food Additives and Contaminants, 17, 627-635 https://doi.org/10.1080/026520300412555
  15. Severn, D.J. (1984): Use of exposure data fgr risk assessment. In: Siewierski, M. (ed.) Determinatlon and assessment of pesticide exposure. Elsevier, New York, 13-19
  16. Tomlin, C. (2000): The pesticide manual (12th edition). British Crop Protection Gguncil, Farnham