Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Interaction effect of Chemical Mixtures

혼합물에서 화학물질간의 상호작용 효과

  • Leem Jong Han (Department of Occupational and Environmental Medicine, Inha University Hospital, University of Inha college of Medicine) ;
  • Shin Joo-Youn (Department of Occupational and Environmental Medicine, Inha University Hospital, University of Inha college of Medicine) ;
  • Kim Yong-Kyu (Department of Occupational and Environmental Medicine, Inha University Hospital, University of Inha college of Medicine)
  • 임종환 (인하대학교 의과대학 산업의학과) ;
  • 신주연 (인하대학교 의과대학 산업의학과) ;
  • 김용규 (인하대학교 의과대학 산업의학과)
  • Published : 2005.06.01
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Abstract

Chemical mixtures of components, each of which are present at less than guidance concentrations, may be hazardous due to additivity, interactions, or both. Toxicological interactions may increase the health hazard above what would be expected from an assessment of each component singly, or all components additively. So chemical mixture are a particular issue in public health. There are several approach to assess whether there are additivity or interaction in assessing toxicological effects, such as, components-based approach, physiologically-based pharmacokinetic /pharmacodynamic(PBPK/PD) models, hazard index method, and weight-of evidence method. If we consider interaction or additivity effects in assessing the health effects of chemcial mixtures, we can get more accurate information about toxicological effects and dose-response relationship in chemical mixtures.

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