Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Effect of Dialysis and Perfusion on Phosphamidon in vitro

투석 및 관류에 의한 살충제 포스파미돈의 제거 효율

  • Hong Sae Yong (Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital) ;
  • Gil Hyo Wook (Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital) ;
  • Yang Jong Oh (Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital) ;
  • Lee Eun Young (Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital)
  • 홍세용 (순천향대학교 천안병원 농약중독연구소) ;
  • 길효욱 (순천향대학교 천안병원 농약중독연구소) ;
  • 양종오 (순천향대학교 천안병원 농약중독연구소) ;
  • 이은영 (순천향대학교 천안병원 농약중독연구소)
  • Published : 2005.06.01
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Abstract

Purfose: This study was to observe the phosphamidon reduction rate after haemoperfusion (HP) and Hemodialysis (HD) in vitro. Methods: We started off by measuring the clearance of HD and HP for the phosphamidon in vitro. Phosphamidon was measured hourly by High-pressure liquid chromatography. Results: Phosphamidon clearance was effectiveness in HP and HD. Phosphamidon reduction rate was no difference between HD and HP; $64\%$ versus $91.\%1$ at starting, $82.2\%$ versus $80.2\%$ at 1 hours, $82.2\%$ versus $73.8\%$ at 2 hours, $34.4\%$ versus $14.0\%$ at 3 hours, $14.1\%$ versus $27.4\%$ at 4 hours, $0\%$ versus $3.3\%$ at 5 hours. Conculsion: Extracorporeal elimination of phosphamidon is effective by hemoperfusio and hemodialysis in vitro. We suggest hemoperfusion may be effective in organophsphate intoxication patients.

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