Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effects of Chitosan on the Lead Level and Histological Changes in Rats Exposed to Various Levels of Lead

납에 노출된 흰쥐의 혈액과 조직의 납 함량 및 병변에 대한 키토산의 섭취효과

  • 박주란 (서울대학교 생활과학대학 식품영양학과) ;
  • 김미혜 (식품의약품 안전청 국립독성연구원) ;
  • 이연숙 (서울대학교 생활과학대학 식품영양학과)
  • Published : 2005.01.01
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Abstract

Chitosan, which is a biopolymer, composed of glucosamine units linked by $\beta$-1, 4 glycoside bonds, is rich in shells of crustacean such as crabs and shrimps. Consumption of chitosan has been rapidly increased as a functional food. We examined effects of chitosan on the damages caused by lead (Pb) exposure in rats. Male Sprague-Dawley rats were divided into 8 groups (n = 64), then fed diets containing 3% cellulose (control) or 3% chitosan, each with 4 different lead doses (0 mg/d, 20 mg/d, 50 mg/d, and 100 mg/d) for 4 wks. Lead doses were given 3 times per week by oral administration. Blood lead levels in rats increased depending on the administered doses of lead. Rats fed chitosan diets showed lower blood lead concentration than did their respective controls. Effect of chitosan on the blood lead was more beneficial in rats exposed to lower lead (20 mg/d) than in rats exposed to higher lead (50 mg/d and 100 mg/d). Histological changes in erythrocytes and liver were also examined. Chitosan tended to reduce numbers of basophilic stippling erythrocytes and improve the histological liver changes in rats given various lead doses. The preventive effects of chitosan on liver damages were stronger in rats with higher lead than those with lower lead. These results indicate that chitosan has beneficial effects on both blood toxicological responses and histological damages of erythrocytes and liver induced by the administration of various lead doses.

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