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Recent Studies on the Edible Plant Vaccine for Prophylactic Medicine against Microorganism-Mediated Diseases

세균성 질병 예방을 위한 식물 경구 백신 연구 동향

  • Hahn Bum-Soo (Plant Metabolic Engineering Team, National Institute of Agricultural Biotechnology) ;
  • Jeong Young-Jae (Plant Metabolic Engineering Team, National Institute of Agricultural Biotechnology) ;
  • Roh Kyung-Hee (Plant Metabolic Engineering Team, National Institute of Agricultural Biotechnology) ;
  • Park Jong-Sug (Plant Metabolic Engineering Team, National Institute of Agricultural Biotechnology) ;
  • Cho Kang-Jin (Plant Metabolic Engineering Team, National Institute of Agricultural Biotechnology) ;
  • Kim Yong-Hwan (Plant Metabolic Engineering Team, National Institute of Agricultural Biotechnology) ;
  • Kim Jong-Bum (Plant Metabolic Engineering Team, National Institute of Agricultural Biotechnology)
  • 한범수 (농업생명공학연구원 신기능소재개발팀) ;
  • 정영재 (농업생명공학연구원 신기능소재개발팀) ;
  • 노경희 (농업생명공학연구원 신기능소재개발팀) ;
  • 박종석 (농업생명공학연구원 신기능소재개발팀) ;
  • 조강진 (농업생명공학연구원 신기능소재개발팀) ;
  • 김용환 (농업생명공학연구원 신기능소재개발팀) ;
  • 김종범 (농업생명공학연구원 신기능소재개발팀)
  • Published : 2005.12.01

Abstract

Plants have considerable advantages for the production of antigenic proteins because they provide an inexpensive source of protein and an easy administration of vaccine. Since a publication describing edible plant vaccine of HBsAg in 1992, a number of laboratories around the world have studied the use of plants as the bioreactor to produce antigenic proteins of human or animal pathogens. Over the last ten years, these works have been mainly focused on three major strategies for the production of antigenic proteins in plants: stable genetic transformation of either the nuclear or plastid genome, or transient expression in plants using viral vectors. As many antigenic proteins have been expressed in tobacco, also several laboratories have succeeded to express genes encoding antigenic proteins in other crop plants: potato, tomato, maize, carrot, soybean and spinach. At present many works for the production of edible plant vaccine against bacteria-mediated diseases have mostly performed the studies of enterotoxins and adhesion proteins. Also the development of new-type antigens (pili, flagella, surface protein, other enterotoxin and exotoxin etc.) is required for various targets and more efficacy to immunize against microorganism pathogens. Many works mostly studied in experimental animals had good results, and phase I clinical trial of LTB clearly indicated its immunogenic ability. On the other hand, edible plant vaccines have still problems remained to be solved. In addition to the accumulation of sufficient antigen in plants, human health, environment and agriculture regulation should be proven. Also oral tolerance, the physiological response to food antigens and commensal flora is the induction of a state of specific immunological unresponsiveness, needs to be addressed before plant-derived vaccine becomes a therapeutic option.

Keywords

References

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