Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effect of chiro-inositol from Soybean on Reducing Hyperglycemia and Its Role for Nutraceutic Supplement for Insulin Resistance

대두 chiro-inositol의 혈당강하효과

  • Hong Yonggeun (Department of Biochemistry, Division of Life Science, College of Natural Sciences, Graduate School of Applied Life Science, Gyeongsang National University) ;
  • Pak Yunbae (Department of Biochemistry, Division of Life Science, College of Natural Sciences, Graduate School of Applied Life Science, Gyeongsang National University)
  • 홍용근 (경상대학교 응용생명과학원 및 자연과학대학 생명과학부 생화학과) ;
  • 박윤배 (경상대학교 응용생명과학원 및 자연과학대학 생명과학부 생화학과)
  • Published : 2005.04.01
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Abstract

Studies with diabetic mammalian systems showed that chiro-inositol administration decreased blood glucose levels. We investigated which foodstuffs contain large amounts of chiro-inositol by surveying vegetables, edible plants and other staples in an effort to explore the nutritional or therapeutic supplements of chiro-inositol for diabetic patients. In the course of our investigation, we found that soybean and soybean derivatives have high chiro-inositol levels (upto 20 mg/g). The purified chiro-inositol from the soybean was then tested for reducing hyperglycemia by administrating the chiro-inositol in streptozotocin-treated diabetic rats. The results showed that the intragastric administration of 50 mg chiro-inositol/kg BW lowered hyperglycemia by $40\%$ and that the effect was sustained for approximately 12 hr.

본 연구는 혈당강하효과를 갖는 chiro-inositol을 다량 함유하고 있는 식품이나 식용물질을 탐색하여 선발하고, 선택된 식품이나 식용물질에서 chiro-inositol을 분리$ {\cdot}$정제하여 정제된 chiro-inositol로 동물실험을 실시하여 혈당강하효과를 증명하였다. 약 300여종의 식품 및 식용물질을 HPLC로 분석한 결과 식품으로 안전한 대두 부산물인 탈지대두와 두부 순물에서 chiro-inositol의 함량이 각각 6.75 mg/g, 20mg/kg로 조사되어 선택되었고, chiro-inositol의 순도가 $90\%$ 이상(w/w)인 chiro-inositol의 추출물을 이용하여 동물실험을 통한 혈당강하효과를 조사하였다. 그 결과, STZ로 유발된 고혈당 쥐에 경구 투여시, 약 $40\%$의 강한 혈당강하 효과를 나타내었으며 지속시간은 약 12시간이었고, 인슐린과 복합처리 했을 때 상승작용(synergy)을 나타내었으며, 저혈당증으로 전혀 발전되지 않았다.

Keywords

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