고지방식이에 의해 비만이 유도된 Zucker Rats에서 상백피분말의 비만 개선효과

Anti-Obesitic Effect of Mulberry Root-Bark (Mori radicis Cortex) in Zucker Rats with High Lipid Diet Induced-Obesity

  • Hong, Seong-Hee (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Dong-Kyu (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Lee, Nam-Jin (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Cho, Jung-Hee (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Kang, Jong-Koo (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Yun-Bae (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Park, Jung-Hui (Park, Jung-Hui Oriental Medical Clinic) ;
  • Hwang, Seock-Yeon (Department of Clinical Laboratory Medicine, Chungbuk National University Hospital)
  • 발행 : 2005.08.31

초록

This study was performed to investigate the anti-obesitic effect of mulberry root-bark on male and female Zucker FA/FA or FA/fa rats. Obesity in the rats was induced by feeding high-lipid diet contained 3% corn oil and 1% cholesterol. Experimental groups in male and female rats were assigned to normal diet group (normal control), high-lipid diet group(positive control) and 3% mulberry root-bark powder in high-lipid diet group (MRC). The mulberry treated-group showed decreases of body weight, FER (food efficiency ratio) value and lipid peroxidation in the liver and increase of high density lipoprotein cholesterol (HDL-C) value, compared with positive control groups. Our findings suggest that mulberry root-bark has a potential role in preventing or improving obesity from the following points of view, body weight, serum lipids and antioxidant enzyme activities.

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