Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Atypical Manifestation of Acute Hemorrhagic Leukoencephalitis (Hurst's Disease)

비전형적인 중상으로 발현한 급성 출혈성 백질뇌염

  • Min, Ju-Hong (Department of Neurology, Seoul National University Hospital, College of Medicine, Seoul National University) ;
  • Lee, Su-Ho (Department of Neurology, Seoul National University Hospital, College of Medicine, Seoul National University) ;
  • Cho, Joong-Yang (Department of Neurology, Ilsan Paik Hospital, College of Medicine, Inje University) ;
  • Park, Sung-Hye (Department of pathology, Seoul National University Hospital, College of Medicine, Seoul National University) ;
  • Lee, Kwang-Woo (Department of Neurology, Seoul National University Hospital, College of Medicine, Seoul National University)
  • 민주홍 (서울대학교병원 신경과) ;
  • 이수호 (서울대학교병원 신경과) ;
  • 조중양 (인제대학교 일산백병원 신경과) ;
  • 박성혜 (서울대학교병원 병리과) ;
  • 이광우 (서울대학교병원 신경과)
  • Published : 2005.05.31
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Abstract

Acute disseminated encephalomyelitis (ADEM) and acute hemorrhagic leukoencephalitis (Hurst's disease) are rare autoimmune demyelinating disorders, which show a monophasic illness with preceding infection. We report a 42-year-old woman presented with multiphasic and progressive neurologic deterioration without definite evidences of infection. She developed hypesthetic ataxia, followed by ipsilateral weakness after a weak, and finally encephalopathy after a month. In contrast to the first MRI showing a small longitudinal lesion, the next images revealed massive bilateral frontal lesions with hemorrhagic necrosis and biopsy unveiled inflammatory demyelination.

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