Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
권호 표지

Comparison of sedative effects using intermittent intravenous bolus injection with tiletamine-zolazepam, xylazine-ketamine, and propofol in beagle dogs

비글견에서 tiletamine-zolazepam, xylazine-ketamine 및 propofol의 간헐적 일시 정맥주사에 의한 진정효과의 비교

  • Lee, Soo-Han (College of Veterinary Medicine, Veterinary Science Research Institute, Konkuk University) ;
  • Bae, Chun-Sik (College of Veterinary Medicine, Biotechnology Research Institute, Chonnam National University) ;
  • Lee, Byeong-han (College of Veterinary Medicine, Veterinary Science Research Institute, Konkuk University) ;
  • Chung, Byung-Hyun (College of Veterinary Medicine, Veterinary Science Research Institute, Konkuk University)
  • 이수한 (건국대학교 수의과대학 및 수의과학연구소) ;
  • 배춘식 (전남대학교 수의과대학 및 생물공학연구소) ;
  • 이병한 (건국대학교 수의과대학 및 수의과학연구소) ;
  • 정병현 (건국대학교 수의과대학 및 수의과학연구소)
  • Accepted : 2005.03.22
  • Published : 2005.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

To compare the sedative effects using intermittent intravenous bolus injection with tiletamine-zolazepam (n = 5, TZ group), xylazine-ketamine (n = 5, XK group) and propofol (n = 5, PI group), we investigated the changes of hemodynamic (heart rate, arterial pressure), $SpO_2$, rectal temperature, respiratory rate and pain score during 60 minute sedation and 40 minute recovery period in beagle dogs. The value of rectal temperature was significantly higher in PI groups (p<0.05) during recovery period. The value of heart rate was significantly lower in XK group (p<0.05) during sedation. The changes of respiratory rate were similar tendency in all groups. The change of $SpO_2$ was stable during sedation and value was significantly higher in PI group (p<0.05) during recovery period. The value of systolic arterial pressure (SAP) was significantly lower in XK group (p<0.05) than PI group during sedation and recovery period. Low analgesic effect occurred in PI group. We concluded that intravenous anesthesia by intermittent bolus injection with propofol is useful in stabilizing rectal temperature, $SpO_2$ and hemodynamic during sedation and provide fast recovery, but have low analgesic effect.

Keywords

References

  1. Branson KR, Gross ME. Propofol in Veterinary Medicine. J Am Vet Med Assoc 1994, 204, 1888-1890
  2. Cullen LK, Reynoldson JA. Xylazine or medetomidine premedication before propofol anaesthesia. Vet Rec 1993, 132, 378-383 https://doi.org/10.1136/vr.132.15.378
  3. Cullen LK, Reynoldson JA. Effects of tiletamine/zolazepam premedication on propofol anesthesia in dogs. Vet Rec 1997, 140, 363-366 https://doi.org/10.1136/vr.140.14.363
  4. Frank SM, Beattie C, Christopherson R, Norris EJ, Rock P, Parker S, Kimball AW Jr. Epidural versus general anesthesia, ambient operating room temperature, and patient age as predictors of inadvertent hypothermia. Anesthesiology 1992, 77, 252-257 https://doi.org/10.1097/00000542-199209001-00252
  5. Hellyer P, Muir WW, Hubbell JA, Sally J. Cardiorespiratory effects of the intravenous of tiletamine-zolazepam to dogs. Vet Surg 1989, 18, 160-165 https://doi.org/10.1111/j.1532-950X.1989.tb01063.x
  6. Ilback NG, Stalhandske T. Cardiovascular effects of xylazine recorded with telemetry in the dog. J Vet Med Series A 2003, 50, 479-483 https://doi.org/10.1111/j.1439-0442.2004.00585.x
  7. Kaplan JA. Cardiac Anesthesia. 3rd ed. p. 521, Saunders, Philadelphia, 1993
  8. Lipton JM, Giesecke AH. Body temperature and shivering in the perioperative patient. Semin Anesth 1988, 7, 3-10
  9. Mama KR, Steffey EP, Pascoe PJ. Evaluation of propofol as a general anesthetic for horses. Vet Surg 1995, 24, 188-194 https://doi.org/10.1111/j.1532-950X.1995.tb01317.x
  10. Martinez EA. Anesthetic agents. In: Boothe DM. (ed.), Small Animal Clinical Pharmacology and Therapeutics. p. 427. Saunders, Philadelphia, 2001
  11. Mirakhur RK, Morgan M. Intravenous anaesthesia: a step forward. Anaesthesia 1998, 53 (Suppl. 1), 1-3 https://doi.org/10.1111/j.1365-2044.1998.00363.x
  12. Sano T, Nishimura R, Mochizuki M, Hara Y, Tagawa M, Sasaki N. Clinical usefulness of propofol as an anesthetic induction agent in dogs and cats. J Vet Med Sci 2003, 65, 641-643 https://doi.org/10.1292/jvms.65.641
  13. Sebel PS, Lowdon JD. Propofol: a new intravenous anesthetic. Anesthesiology 1989, 71, 260-277 https://doi.org/10.1097/00000542-198909001-00260
  14. Shafer SL. Advances in propofol pharmacokinetics and pharmacodynamics. J Clin Anesth 1993, 5 (Suppl 1), 14S-21S https://doi.org/10.1016/0952-8180(93)90003-W
  15. Shapiro BA, Peruzzi WT, Templin R. Clinical Application of Blood Gases. 5th ed. p. 64. Mosby, St. Louis, 1994
  16. Short CE, Bufalari A. Propofol anesthesia. Vet Clin North Am Small Anim Pract 1999, 29, 747-778 https://doi.org/10.1016/S0195-5616(99)50059-4
  17. Stephan H, Sonntag H, Schenk HD, Kettler D, Khambatta HJ. Effects of propofol on cardiovascular dynamics, myocardial blood flow and myocardial metabolism in patients with coronary artery disease. Br J Anaesth 1986, 58, 969-975 https://doi.org/10.1093/bja/58.9.969
  18. Vermeyen KM, Erpels FA, Janssen LA, Beeckman CP, Hanegreefs GH. Propofol-fentanyl anaesthesia for coronary bypass surgery in patients with good left ventricular function. Br J Anaesth 1987, 59, 1115-1120 https://doi.org/10.1093/bja/59.9.1115