Hepatoprotective Constituents of Cudrania tricuspidata

  • Tian Yu-Hua (College of Pharmacy and Phytofermentation Research Center, Wonkwang university) ;
  • Kim Hyun-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang university) ;
  • Cui Jiong-Mo (College of Medicine, Yanbian University) ;
  • Kim Youn-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang university)
  • Published : 2005.01.01

Abstract

Phytochemical investigation of the MeOH extract of the root barks of Cudrania tricuspidata Bureau (Moraceae), as guided by hepatoprotective activity in vitro, furnished four isoprenylated xanthones, cudratricusxanthone A (1), cudraxanthone L (2), cudratricusxanthone E (3), and macluraxanthone B (4). All of these compounds showed the significant hepatoprotective effect on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Compounds 1, 2, and 4 also exhibited the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.

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