Hepatoprotective Constituents of Cudrania tricuspidata

  • Tian Yu-Hua (College of Pharmacy and Phytofermentation Research Center, Wonkwang university) ;
  • Kim Hyun-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang university) ;
  • Cui Jiong-Mo (College of Medicine, Yanbian University) ;
  • Kim Youn-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang university)
  • Published : 2005.01.01


Phytochemical investigation of the MeOH extract of the root barks of Cudrania tricuspidata Bureau (Moraceae), as guided by hepatoprotective activity in vitro, furnished four isoprenylated xanthones, cudratricusxanthone A (1), cudraxanthone L (2), cudratricusxanthone E (3), and macluraxanthone B (4). All of these compounds showed the significant hepatoprotective effect on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Compounds 1, 2, and 4 also exhibited the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.


  1. Amit, G., Cohen, P., and Ackerman, Z., Nitrofurantoin-induced chronic active hepatitis. Isr. Med. Assoc. J., 4, 184-186 (2002)
  2. Edoute, Y., Karmon, Y., Roguin, A., and Ben-Ami, H., Fatal liver necrosis associated with the use of nitrofurantoin. Isr. Med. Assoc. J., 3, 382-383 (2001)
  3. Grant, M. H., Duthie, S. J., Gray, A. G., and Bruke, M. D., Mixed function oxidase and UDP-glucuronyltransferase activities in the human Hep G2 hepatoma cell line. Biochem. Pharmacol., 37, 4111-4116 (1988) https://doi.org/10.1016/0006-2952(88)90103-7
  4. Groweiss, A., Cardellina, J. H., and Boyd, M. R., HIV-inhibitory prenylated xanthones and flavones from Maclura tinctoria. J. Nat. Prod., 63, 1537-1539 (2000) https://doi.org/10.1021/np000175m
  5. Hano, Y., Matsumoto, Y., Shinohara, K., Sun, J. Y., and Nomura, T., Structures of four isoprenylated xanthones, cudraxanthones L, M, N, and O from Cudrania tricuspidata., 57, 172-175 (1991) https://doi.org/10.1055/s-2006-960059
  6. Jiang su New Medical College. Encyclopedia of Chinese medicinal substances. Shanghai Peoples Publisher, Shanghai, p. 1502 (1977)
  7. Kelly, B. D., Heneghan, M. A., Bennani, F., Connolly, C. E., and O'Gorman T. A., Nitrofurantoin-induced hepatotoxicity mediated by CD8+ T cells. Am. J. Gastroenterol., 93, 819- 821 (1998)
  8. Klee, S., Nurnberger, M. C., and Ungemach, F. R., The consequences of nitrofurantoin-induced oxidative stress in isolated rat hepatocytes: evaluation of pathobiochemical alterations. Chem. Biol. Interact., 93, 91-102 (1994) https://doi.org/10.1016/0009-2797(94)90089-2
  9. Osseni, R. A., Debbasch, C., Christen, M. O., Rat, P., and Warnet, J. M., Tacrine-induced reactive oxygen species in a human liver cell line: the role of anethole dithiolethione as a scavenger. Toxicol. In Vitro, 13, 683-688 (1999) https://doi.org/10.1016/S0887-2333(99)00050-8
  10. Song, E. K., Cho, H., Kim, J.S., Kim, N.Y., An, N. H., Kim, J. A., Lee, S. H., and Kim, Y.C., Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa. Planta Med., 67, 876-877 (2001) https://doi.org/10.1055/s-2001-18860
  11. Watkins, P. B., Zimmerman, H. J., Knapp, M. J., Gracon, S. I., and Lewis, K. W., Hepatotoxic effects of tacrine administration in patients with Alzheimers disease. J. Am. Med. Assoc., 271, 992-998 (1994) https://doi.org/10.1001/jama.271.13.992
  12. Zou, Y. S., Hou, A. J., Zhu, G. F., Chen, Y. F., Sun, H. D., and Zhao, Q. S., Cytotoxic isoprenylated xanthones from Cudrania tricuspidata. Bioorg. Med. Chem., 12, 1947-1953 (2004) https://doi.org/10.1016/j.bmc.2004.01.030