Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
권호 표지

The Systemic Effects of Hypothermic and Normothermic Cardiopulmonary Bypass in Cardiac Surgery

심장수술시 저체온 체외순환과 정상체온 체외순환의 전신 효과에 관한 연구

  • Park Jae Min (Deparment of Thoracic & Cardiovasclar Surgery, Pusan Paik Hospital College of Mediine, Inje University) ;
  • Cho Yong Gil (Deparment of Thoracic & Cardiovasclar Surgery, Pusan Paik Hospital College of Mediine, Inje University) ;
  • Hwang Yoon Ho (Deparment of Thoracic & Cardiovasclar Surgery, Pusan Paik Hospital College of Mediine, Inje University) ;
  • Lee Yang Haeng (Deparment of Thoracic & Cardiovasclar Surgery, Pusan Paik Hospital College of Mediine, Inje University) ;
  • Yoon Young Chul (Deparment of Thoracic & Cardiovasclar Surgery, Pusan Paik Hospital College of Mediine, Inje University) ;
  • Junng Hee Jae (Deparment of Thoracic & Cardiovasclar Surgery, Pusan Paik Hospital College of Mediine, Inje University) ;
  • Han Il Yong (Deparment of Thoracic & Cardiovasclar Surgery, Pusan Paik Hospital College of Mediine, Inje University) ;
  • Choi Seok Cheol (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Cho Kwang Hyun (Deparment of Thoracic & Cardiovasclar Surgery, Pusan Paik Hospital College of Mediine, Inje University)
  • 박재민 (인제대학교 의과대학 부산백병원 흉부외과학교실) ;
  • 조용길 (인제대학교 의과대학 부산백병원 흉부외과학교실) ;
  • 황윤호 (인제대학교 의과대학 부산백병원 흉부외과학교실) ;
  • 이양행 (인제대학교 의과대학 부산백병원 흉부외과학교실) ;
  • 윤영철 (인제대학교 의과대학 부산백병원 흉부외과학교실) ;
  • 전희재 (인제대학교 의과대학 부산백병원 흉부외과학교실) ;
  • 한일용 (인제대학교 의과대학 부산백병원 흉부외과학교실) ;
  • 최석철 (부산가톨릭대학교 보건과학대학 임상병리학과) ;
  • 조광현 (인제대학교 의과대학 부산백병원 흉부외과학교실)
  • Published : 2005.01.01
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Abstract

This study was prospectively designed to determine the physiologic effects of normothermic CPB and to compare its influences with hypothermic CPB. Material and Method: Thirty-six adult patients scheduled for el­ective cardiac surgery were randomly assigned to moderate hypothermic (hypothermic group nasopharyngeal tem­perature $26\~28^{\circ}C,\;n=18)$ ornormothermic (normothermic group, nasopharyngeal temperature > $35.5^{\circ}C\;n=18)$ CPB. Arterial blood samples were taken before CPB (Pre-CPB), 10 minutes after the start of CPB (CPB-10), and imme­diately after CPB stop (CPB-off) for determining total leukocyte counts, neuron-specific enolase (NSE), interleukin-6 (IL-6), endothelin-1 (ET-1), cortisol, troponin I (TNI), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, blood urea nitrogen (BUN), and the pulmonary index $(Pi,\;PaO_{2}/FiO_{2}),$Other parameters such as urine output, mechanical ventilating period, ICU-staying period, postoperative complications and hospitalized days were also evaluated. Result: Total leukocyte counts, increased rate in NSE, in IL-6 and in cortisol at CPB-10 and CPB-off were significantly higher in normothermic group than in hyphothermic group. Urine output during CPB was lower in normothermic group than in hyphothermic group. The duration of mechanical ventilation, ICU-stay, and hospitalization were longer in normothermic group than in hyphothermic group. Conclusion: These findings sug­gested that normothermic CPB caused higher inflammatory and stress responses than hypothermic CPB during car­diac surgery using cold crystalloid cardioplegia. However, further studies with large number of cases should be carried out to validate this hypothesis.

저자득은 최근 논의되고 있는 정상체온 체외순환의 임상적 유용성과 생리학적 영향을 규명하기 위해 저체온 체외순환과의 비교 연구를 시행하게 되었다. 대상 및 방법: 심장수술이 계획된 36명의 성인 환자들을 연구목적에 따라 무작위로 중등도 저 체온 체외순환군(이하 저체온군, 비인두 온도$26\~28^{\circ}C,\;n=18)$과 정상체온 체외순환군(이하 정상체온군, 비인두 온도>,$35.5^{\circ}C,\;n=18)$으로 나누었다. 전체 환자들로부터 체외순환 전, 체외순환 중, 체외순환 종료 직후에 각각 혈액을 채취하여 총 백혈구 수, neuron-specific enolase 증가율(NSE), interleukin-6 증가율(IL-6), endothelin-1 (ET-1), cortisol 증가율, troponin I (TNI), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, blood urea nitrogen (BUN)을 측정하였다. 그 외 수술 중 소변 배출량, 수술 후 페지수$(PaO_{2}/FiO_{2}),$ 기계호흡 보조시간, 중환자실 치료기간, 합병증, 재원일수 등을 조사하여 양 군 간에 비교 평가하였다 결과: 정상체온군이 저체온군에 비해 심장수술 동안 총 백혈구 수, NSE 증가율, IL-6 증가율, cortisol 증가율은 유의하게 더 높았으나 소변 배출량은 더 낮았다. 또한 기계 호흡 보조 시간, 중환자실 치료기간, 재원일수 역시 정상체온군이 저체온군보다 유의하게 더 길었다. 결론: 저자들의 연구 결과를 볼 때 정질 냉각 심정지액을 이용한 심장 수술 동안 정상체온 체외순환은 중등도저체온 체외순환보다 더 높은 염증 및 스트레스 반응을 유도하여 생리학적으로 유해할 것으로 생각된다. 그러나 좀더 많은 환자 수를 대상으로 한 추가적 연구가 필요할 것으로 판단된다.

Keywords

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