Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Anti-Estrogenic Activity of Lignans from Acanthopanax chiisanensis Root

  • Lee Sanghyun (College of Pharmacy, Seoul National University) ;
  • Yoo Hye Hyun (College of Pharmacy, Seoul National University) ;
  • Piao Xiang Lan (College of Pharmacy, Seoul National University) ;
  • Kim Ju Sun (Natural Products Research Institute, Seoul National University) ;
  • Kang Sam Sik (Natural Products Research Institute, Seoul National University) ;
  • Shin Kuk Hyun (Natural Products Research Institute, Seoul National University)
  • Published : 2005.02.01
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Abstract

Anti-estrogenic activity of (-)-sesamin (1), helioxanthin (2), savinin (3), taiwanin C (4), and 3­(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone (5) isolated from the root of Acanthopanax chiisanensis was tested using Ishikawa cells. Among them, compound 3 exhibited anti-estrogenic activity ($IC_{50}\;=\;4.86\;{\mu}M$).

Keywords

References

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