The KIPS Transactions:PartD (정보처리학회논문지D)

Korea Information Processing Society (한국정보처리학회)
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Comparison and Analyzing System for Protein Tertiary Structure Database expands LOCK

LOCK을 확장한 3차원 단백질 구조비교 및 분석시스템의 설계 및 구현

  • 정광수 (충북대학교 대학원 전자계산학과) ;
  • 한욱 (충북대학교 대학원 전자계산학과) ;
  • 박성희 (충북대학교 대학원 전자계산학과) ;
  • 류근호 (충북대학교 전기전자컴퓨터공학부)
  • Published : 2005.04.01
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Abstract

Protein structure is highly related to its function and comparing protein structure is very important to identify structural motif, family and their function. In this paper, we construct an integrated database system which has all the protein structure data and their literature. The structure queries from the web interface are compared with the target structures in database, and the results are shown to the user for future analysis. To constructs this system, we analyze the Flat-File of Protein Data Bank. Then we select the necessary structure data and store as a new formatted data. The literature data related to these structures are stored in a relational database to query the my kinds of data easily In our structure comparison system, the structure of matched pattern and RMSD valure are calculated, then they are showed to the user with their relational documentation data. This system provides the more quick comparison and nice analyzing environment.

단백질의 구조는 단백질의 기능과 밀접한 연관을 가지고 있으며 단백질 구조비교는 단백질의 모티프와 패밀리를 결정하고 나아가서 그들의 기능을 파악하는데 매우 중요한 역할을 한다. 이 논문에서는 단백질 구조데이터 및 관련된 문헌 데이터의 통합된 데이터베이스를 구축하고 웹 환경에서 질의된 단백질과 유사성 비교를 진행하여 그 결과 및 연관된 문헌데이터를 검색하여 체계적으로 정보를 제공하는 단백질 분석시스템을 제안한다. 제안 시스템을 구축하기 위하여 현재까지 가장 큰 단백질 구조데이터의 저장소인 Protein Data Bank의 플랫파일 데이터에 대해 분석을 진행하고 여기에서 단백질의 구조비교 알고리즘에 필수적인 구조데이터정보를 추출하여 새로운 구조비교에 사용되는 엔트리 플랫 파일을 만들어서 데이터베이스를 구축한다 이러한 엔트리에 연관된 분석정보 데이터는 데이터베이스 스키마를 작성하여 문헌정보 데이터베이스를 구축한다. 따라서 사용자가 인터넷을 통하여 진행한 질의는 구조비교엔진을 통하여 유사부분과 RMSD값이 계산되고 이와 연관된 문헌정보의 검색이 진행된 후 체계적으로 출력화면에 보여준다. 제안 시스템은 기존의 구조비교시스템보다 빠른 검색을 지원하고 더 훌륭한 분석환경을 제공한다.

Keywords

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