Bulletin of the Korean Chemical Society

  • 제27권1호
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  • Pages.59-64
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  • 2006
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Understanding the RNA-Specificity of HCV RdRp: Implications for Anti-HCV Drug Discovery

  • Kim, Jin-young (Department of Biomedical Science and Technology, Konkuk University) ;
  • Chong, You-hoon (Department of Biomedical Science and Technology, Konkuk University)
  • 발행 : 2006.01.20
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초록

Unlike other viral polymerases, HCV RNA-dependent RNA polymerase (RdRp) has not been successfully inhibited by nucleoside analogues presumably due to its strong substrate specificity for RNA. Thus, in order to understand the RNA-specificity of HCV RdRp, the structural characteristics of the active site was investigated. The hereto unknown 2-OH binding pocket at the active site of RdRp provides invaluable implication for the development of novel anti-HCV nucleoside analogues.

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피인용 문헌

  1. Nucleotide Prodrugs of 2′-Deoxy-2′-spirooxetane Ribonucleosides as Novel Inhibitors of the HCV NS5B Polymerase vol.57, pp.5, 2014, https://doi.org/10.1021/jm4015422
  2. Thiobarbituric Acid Derivatives for Anti-HCV Agents Targeting NS5B RNA Polymerase vol.28, pp.11, 2006, https://doi.org/10.5012/bkcs.2007.28.11.1917
  3. 2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase vol.53, pp.22, 2010, https://doi.org/10.1021/jm101050a