DOI QR코드

DOI QR Code

Protective Effect of Panax ginseng extract on Renal Functions Altered by Mercuric Chloride in Albino Rats

  • Saxena, Prabhu-N. (Toxicology Laboratory, Department of Zoology, School of Life Sciences, Khandari Campus, DR. B.R. Ambedkar University) ;
  • Mahour, K. (Toxicology Laboratory, Department of Zoology, School of Life Sciences, Khandari Campus, DR. B.R. Ambedkar University) ;
  • Kumar, Ashok (Cancer and Radiation Biology Laboratory Department of Zoology University)
  • Published : 2006.09.30

Abstract

Liver and kidney are specific organs which play an active role in biotransformation and detoxification mechanisms. Ant adverse effect of chemicals or heavy metal can cause the delay or fade in these mechanisms. Present study was designed to find out the protective effect of Panax ginseng extract on renal functions altered by mercuric chloride (heavy metal) in albino rat. Fifty albino rats were divided into 10 groups. Five groups for acute study and five groups for sud-acute study viz. control group (Tween 20 and distilled water), mercuric chloride treated group (0.926 mg/kg body wt. for acute and 0.044 mg/kg body wt. for sub-acute group after calculated $LD_{50}$ (9.26 mg/kg body wt.) by probit analysis (Finney, 1971), Panax ginseng extract treated group (10 mg/kg body wt. for acute and sub-acute sets), mercuric chloride treated followed by Panax ginseng extract and Panax ginseng extract followed by mercuric chloride group. All doses were given orally by gavage tube. The result revealed that the serum urea and creatinine significantly increased in mercuric chloride treated group, while significantly decreased (p<0.01) in Panax ginseng extract group after acute and sub-acute treatment. The biochemical estimation is also confirmed by nephropathological aspect. However, the Panax ginseng extract treated followed by mercuric chloride group is more prominent than the mercuric chloride treated followed by Panax ginseng extract group. It can be concluded that Panax ginseng extract had a protective nature on renal functions against mercuric chloride toxicity in albino rats.

Keywords

References

  1. Goyer, R.A. : environmentally related disease of the urinary tract. Environ.med.74, 377-389 (1990)
  2. Hojo, Y. and Satomi, Y. : in vitro nephrotoxicity induced in mice by chromium (VI): involvement of glutathione and chromium (V). Biol. Trace. Elem. Res. 31, 21-31 (1991) https://doi.org/10.1007/BF02990356
  3. Laborda, R., Diaz-Mayants, j., and Nurez, A. : Nephrotoxic and hepatotoxic effects of chromium compounds in rats. Bull. Environ. Contam. Toxicol. 36, 332-336 (1986) https://doi.org/10.1007/BF01623516
  4. Finney, D.J. : Probit analysis. Cambridge University press, pp.303 (1971)
  5. Facino, R.M., Carini, M., Aldini, G., Berti, F. and Rossoni, G. Panax ginseng extract administration in the rat prevents myocardial ischemia-reperfusion damage induced by hyperbaric oxygen: evidence fro an antioxidant intervention. Planta. Medica. 65, 614-619 https://doi.org/10.1055/s-1999-14034
  6. Tietz, N.W.: in clinical guide to laboratory tests, W.B. Saunders Co. London, pp 492 (1983)
  7. Kammcraat, C. (1978). Clin. Chem. Acta. 84, 119 https://doi.org/10.1016/0009-8981(78)90484-9
  8. Abdel – Wahhab, M.A., Nada, S.A. and Khalil, F.A.: Physiological and toxicological responses in rats fed aflatoxincontaminated diet with or without sorbent materials. J. Agrie. Sci. Mansoura Univ. 24(4), 1713-1725 (1999)
  9. Kumar, A. and Rana. S.V.S.: enzymological effects of hexavalent chromium in the rat kidney. Int.J.Tissue.React. 6(2), 135-139 (1984)
  10. Yokozama, T. and Liu, Z.W.: The role of ginsenoside-Rd in cisplatin-induced acute and renal failure. Ren.Fail. 22(2), 115-127 (2000) https://doi.org/10.1081/JDI-100100858
  11. Ballantyne, B., Mars, T., and Syversen, T.: General and Applied Toxicology. p.853-891.3rd vol. Macmillan Reference Ltd, London (1999)

Cited by

  1. Phytoremedial Effect of <i>Pleurotus cornucopiae</i> (Oyster Mushroom) against Sodium Arsenite Induced Toxicity in Charles Foster Rats vol.05, pp.12, 2014, https://doi.org/10.4236/pp.2014.512120