Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

The Effect of Plantaginis Semen on $CCI_4$ Induced Hepatoxicity in Rats

차전자(車前子)의 약침(藥鍼) 및 경구투여(經口投與)가 백서(白鼠) 간손상(肝損傷)에 미치는 영향(影響)

  • Kwon, Seon-Ho (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongeui University) ;
  • Kim, Cheol-Hong (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Youn, Hyoun-Min (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Jang, Kyung-Jeon (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Ahn, Chang-Beohm (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongeui University) ;
  • Kim, Hoon (Dept. of Medical History, College of Oriental Medicine, Dongeui University) ;
  • Song, Choon-Ho (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongeui University)
  • 권선호 (동의대학교 한의과대학 경혈학교실) ;
  • 김철홍 (동의대학교 한의과대학 침구학교실) ;
  • 윤현민 (동의대학교 한의과대학 침구학교실) ;
  • 장경전 (동의대학교 한의과대학 침구학교실) ;
  • 안창범 (동의대학교 한의과대학 침구학교실) ;
  • 김훈 (동의대학교 한의과대학 의사학교실) ;
  • 송춘호 (동의대학교 한의과대학 경혈학교실)
  • Published : 2006.06.27
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Abstract

Objectives: This study was undertaken to determine if Plantaginis Semen(PS) has a protective effect against $CCI_4$ induced hepatoxicity in Rats. Methods: The experimental groups were divided into Normal group (untreated Group), Control group $(group\;treated\;with\;CCI_4)$, Sample 1 (group treated with 0.1 ml Plantaginis Semen herbal acupuncture in both sides of $G\bar{a}nsh\bar{u}\;(BL_{18})$ after $CCI_4$ treating) and Sample 2 (group treated with feeding of 1 cc Plantaginis Semen extraction after $CCI_4$ treating). Rats were administered orally $CCI_4\;(0.1\;ml/kg)$ for 4 days. In experiments for PS effect, rats of Sample 1 group received 0.lml herbal acupuncture of PS extraction in both sides of corresponding $G\bar{a}nsh\bar{u}\;(BL_{18})$ of human body for 3 days after treated $CCI_4$. Rats of Sample 2 group feeded PS extraction (1cc) for 3 days after treated $CCI_4$. Variation of weight and biochemical assays (AST, ALT, LDH, ALP, total cholesterol, triglyceride, total protein, albumin) were performed. Results: In Control group, $CCI_4$ increased serum AST, ALT, LDH, ALP, total protein, albumin and decreased weight, total cholesterol, triglyceride. Sample 1 and Sample 2 significantly decreased serum AST, ALT, LDH, ALP, total protein, albumin as compared with Control group. Conclusion: These results indicate that PS could be used in prevention and treatment of hepatoxicity. However, precise mechanisms of PS protection remain to be determined.

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