Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Effect of scutellariae radix pharmacopuncture on the type 1 hypersensitivity

황금약침(黃芩藥鍼)이 Type 1 Hypersensitivity에 미치는 영향

  • Kim, Yu-Seung (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongeui University) ;
  • Song, Choon-Ho (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongeui University)
  • 김유승 (동의대학교 한의과대학 경혈학교실) ;
  • 송춘호 (동의대학교 한의과대학 경혈학교실)
  • Published : 2006.09.27
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Abstract

Objectives : We studied the effects of Scutellariae Radix pharmacopuncture solution (SRHAS) on the type 1 hypersensitivity. Methods : In vivo, we measured compound 48/80-induced active systemic anaphylactic shock using ICR mice and anti-DNP IgE-induced passive cutaneous anaphylaxis (PCA) using Sprague Dawley rats. In vitro, we showed effects on cytotoxicity and ${\beta}-hexosaminidase$ release from RBL-2H3 cells. Results : In vivo, SRHAS pretreatments (100% or 50%) at BL13 inhibited active systemic anaphylactic shock induced by compound 48/80. PCA was only inhibited by pretreatments of SRHAS at optional points. In vitro, $0.1{\sim}2%$ SRHAS treatments did not affect cell viability while ${\beta}$-hexosaminidase release was significantly inhibited. Conclusions : These results suggest that SRHAS may be beneficial in the inhibition of type I hypersensitive inflammatory response.

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