The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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The Inhibitory Effects of Poncirin against Nickel Induced Cytotoxicity

Poncirin의 니켈에 대한 세포독성억제효과

  • Yang, Seung-Jin (Department of Oral Anatomy, School of Dentistry, Wonkwang University) ;
  • Kwak, Dong-Keun (Department of Oral Anatomy, School of Dentistry, Wonkwang University) ;
  • Han, Du-Suk (Department of Oral Anatomy, School of Dentistry, Wonkwang University)
  • 양승진 (원광대학교 치과대학 구강해부학교실) ;
  • 곽동근 (원광대학교 치과대학 구강해부학교실) ;
  • 한두석 (원광대학교 치과대학 구강해부학교실)
  • Published : 2006.06.30
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Abstract

Objectives : Nickel is a major metal used in the nickel-chromium alloys of most orthodontic appliances, partial denture and implants. This study was carried out for the examination of the cytotoxicity on nickel sulfide in cultured NIH3T3 fibroblasts, and poncirin effect on nickel-induced cytotoxicity. Methods : Cell viability for the MTT assay and cell adhesion activity for the XTT assay. Results : The $IC_{50}$ of nickel sulfide by the MTT assay was $93.7\;{\mu}M$. Poncirin was significantly increased the cell viability and cell adhesion activity. Conclusion : Nickel was highly toxic and poncirin has the inhibitory effects against nickel induced cytotoxicity.

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