Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Relationships Between the Larval Growth Inhibition of Caenorhabditis elegans by Apigenin Derivatives and Their Structures

  • Yoon, Young-Ah (Bio/Molecular Informatics Center, Division of Bioscience and Biotechnology, Konkuk University) ;
  • Kim, Ho-Jung (Bio/Molecular Informatics Center, Division of Bioscience and Biotechnology, Konkuk University) ;
  • Lim, Yoong-Ho (Bio/Molecular Informatics Center, Division of Bioscience and Biotechnology, Konkuk University) ;
  • Shim, Yhong-Hee (Bio/Molecular Informatics Center, Division of Bioscience and Biotechnology, Konkuk University)
  • Published : 2006.07.01
Download PDF
⟨ Previous Next ⟩

Abstract

Due to consumer reluctance to take synthetic drugs for nematode infections and the appearance of resistance to anthelminthic drugs, new drugs from natural products must be developed. Caenorhabditis elegans is one of the freely living nematodes and serves as a good model system for screening anthelminthic drugs. In this study, thirteen flavonoid derivatives were tested for anthelminthic activity and the relationships between their activities and structures were investigated. The structural information combined with the data for the larval growth inhibition of C. elegans provided meaningful structural insights in the search for new anthelminthic drugs.

Keywords

References

  1. Brenner, S., The genetics of Caenorhabditis elegans. Genetics, 77, 71-94 (1974)
  2. Cook, N. C. and Samman, S., Flavonoids - chemistry, metabolism, cardioprotective effects, and dietary sources. J. Nutr. Biochem., 7, 66-76 (1996) https://doi.org/10.1016/0955-2863(95)00168-9
  3. Hempel, J., Pforte, H., Raab, B., Engst, W., Bohm, H., and Jacobasch, G., Flavonols and flavones of parsley cell suspension culture change the antioxidative capacity of plasma in rats. Nahrung, 43, 201-204 (1999) https://doi.org/10.1002/(SICI)1521-3803(19990601)43:3<201::AID-FOOD201>3.0.CO;2-1
  4. Miean, K. H. and Mohamed, S., Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J. Agric. Food. Chem., 49, 3106-12 (2001) https://doi.org/10.1021/jf000892m
  5. Sulston, J. E., Schierenberg, E., White, J. G., and Thomson, J. N., The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol., 100, 64-119 (1983) https://doi.org/10.1016/0012-1606(83)90201-4
  6. Torkin,R., Lavoie, J. F., Kaplan, D. R., and Yeger, H., Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma. Mol. Cancer Ther., 4, 1-11 (2005) https://doi.org/10.1186/1476-4598-4-1
  7. Wood, W. B., The Nematode Caenorhabditis elegans, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, PP. 1-16 (1988)
  8. Yang, H., Ahn, J. H., Jeong, K. J., Lee, S., and Lim, Y., The Homodimerization of Thalictrum tuberosum O-methyltransferases by Homology-based Modelling. Bull. Korean Chem. Soc., 24, 1256-1260 (2003) https://doi.org/10.5012/bkcs.2003.24.9.1256