Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Antiplatelet and Antithrombotic Activities of Korean Red Ginseng

  • Yu, Ji-Yeon (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) ;
  • Jin, Yong-Ri (Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Lee, Jung-Jin (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) ;
  • Chung, Jin-Ho (College of Pharmacy, Seoul National University) ;
  • Noh, Ji-Yoon (College of Pharmacy, Seoul National University) ;
  • You, Soon-Hyang (Department of Food and Nutrition, Chungbuk National University) ;
  • Kim, Ki-Nam (Department of Food and Nutrition, Chungbuk National University) ;
  • Im, Ji-Hyun (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) ;
  • Lee, Ju-Hyun (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) ;
  • Seo, Ji-Min (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) ;
  • Han, Hyeong-Jun (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) ;
  • Lim, Yong (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) ;
  • Park, Eun-Seok (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) ;
  • Kim, Tack-Joong (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) ;
  • Shin, Kyeong-Soeb (College of Medicine, Chungbuk National University) ;
  • Wee, Jae-Joon (KT & G Central Research Institute) ;
  • Park, Jong-Dae (KT & G Central Research Institute) ;
  • Yun, Yeo-Pyo (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University)
  • Published : 2006.10.01
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Abstract

The antiplatelet and antithrombotic activities of Korean Red Ginseng (KRG) were examined on rat carotid artery thrombosis in vivo, and platelet aggregation in vitro and ex vivo. Administration of KRG to rats not only prevented carotid artery thrombosis in vivo in a dose-dependent manner, but also significantly inhibited ADP- and collagen-induced platelet aggregation ex vivo, while failed to prolong coagulation times such as activated partial thromboplastin time (APTT) and prothrombin time (PT), indicating the antithrombotic effect of KRG might be due to its anti platelet aggregation rather than anticoagulation effect. In line with the above observations, KRG inhibited U46619-, arachidonic acid-, collagen- and thrombin-induced rabbit platelet aggregation in vitro in a concentration-dependent manner, with $IC_{50}$ values of $620{\pm}12$, $823{\pm}22$, $722{\pm}21$ and $650{\pm}14\;{\mu}g/mL$, respectively. Accordingly, KRG also inhibited various agonists-induced platelet serotonin secretions as it suppressed platelet aggregation. These results suggest that KRG has a potent antithrombotic effect in vivo, which may be due to antiplatelet rather than anticoagulation activity, and KRG intake may be beneficial to the individuals with high risks of thrombotic and cardiovascular diseases.

Keywords

References

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