The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Short-Term High Expression of Interferon-Alpha Modulates Progression of Type 1 Diabetes in NOD Mice

  • Park, Mi-Kyoung (Departments of Internal Medicine, Dong-A University College of Medicine) ;
  • Seo, Su-Yeong (Departments of Microbiology, Dong-A University College of Medicine) ;
  • Hong, Sook-Hee (Departments of Pathology, Dong-A University College of Medicine) ;
  • Kim, Hye-Jin (Departments of Pharmacology, Dong-A University College of Medicine) ;
  • Park, Eun-Jin (Departments of Pharmacology, Dong-A University College of Medicine) ;
  • Kim, Duk-Kyu (Departments of Internal Medicine, Dong-A University College of Medicine) ;
  • Lee, Hye-Jeong (Departments of Pharmacology, Dong-A University College of Medicine)
  • Published : 2006.02.21
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Abstract

Type I diabetes (T1D) is an organ-specific autoimmune disease caused by the T cell-mediated destruction of the insulin-producing ${\beta}$ cells in the pancreatic islets. The onset of T1D is the consequence of a progressive destruction of islet ${\beta}$ cells mediated by an imbalance between effector $CD4^+$ T helper (Th)1 and regulatory $CD4^+$ Th2 cell function. Since interferon-alpha (IFN-${\alpha}$) has been known to modulate immune function and autoimmunity, we investigated whether administration of adenoviralmediated IFN-${\alpha}$ gene would inhibit the diabetic process in NOD mice. The development of diabetes was significantly inhibited by a single injection of adenoviral-mediated IFN-${\alpha}$ gene before 8 weeks of age. Next, we examined the hypothesis that Th2-type cytokines are associated with host protection against autoimmune diabetes, whereas Th1-type cytokines are associated with pathogenesis of T1D. The expression of IFN-${\alpha}$ induced increase of serum IL-4 and IL-6 (Th2 cytokines) levels and decrease of serum IL-12 and IFN-${\gamma}$ (Th1 cytokines) levels. Therefore, overexpression of IFN-${\alpha}$ by adenoviralmediated delivery provides modulation of pathogenic progression and protection of NOD mice from T1D.

Keywords

References

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