Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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Supplementary Effect of the Giant Embryonic Rice on Serum and Heaptic Lipid Levels of Streptozotocin-induced Diabetic Rats

Streptozotocin 유발 당뇨 쥐의 거대배아미 식이에 의한 혈액 및 간조직의 지질조성

  • Lee, Youn-Ri (Department of Food Science and Nutrition, Kyungpook National University) ;
  • Kim, Chae-Eun (Department of Food Science and Nutrition, Kyungpook National University) ;
  • Nam, Seok-Hyun (Department of Biological Science, Ajou University) ;
  • Kang, Mi-Young (Department of Food Science and Nutrition, Kyungpook National University)
  • 이연리 (경북대학교 식품영양학과) ;
  • 김채은 (경북대학교 식품영양학과) ;
  • 남석현 (아주대학교 자연과학부) ;
  • 강미영 (경북대학교 식품영양학과)
  • Published : 2006.08.01
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Abstract

This study was carried out to investigate the supplementary effects of giant embryonic rice, which has over two times of embryo size compared the normal rice, on lipid metabolism of insulin dependent diabetic rats. Streptozotocin induced diabetic rats were fed four kinds of experimental diets com starch diet as a control (C-D), a polished rice diet (R-D), a brown rice diet (BR-D) and a giant embryonic rice diet (GER-D) respectively, for 6 weeks. Diet intake body weight, organ weights and lipid levels of serum, liver and feces were measured. There was significant difference in diet intake and body weight among experimental groups. The concentrations of serum triglyceride and total serum cholesterol of BR-D and GER-D groups were lower than those of others. The total hepatic cholesterol level was the lowest in GER-D group. The contents of total lipid and total cholesterol excreted in feces of BR-D and GER-D groups were higher than those of C-D and R-D groups. These results suggested the giant embryonic rice diets can effectively reduce serum triglyceride level and total hepatic cholesterol level in insulin dependent diabetic rats, and hypolipidemic effects be due to increasing fecal lipid excretion.

본 연구는 거대배아미 급여가 당뇨모델의 지질대사에 미치는 영향을 검토하고자 수행되었다. 실험모델은 스트렙토조토신으로 유발된 인슐린 의존형 당뇨 흰쥐를 이용하여, 실험식이를 6주간 급여한 후의 체내 지질함량 및 대변으로의 배설량을 각각 조사 하였다 거대배아미를 급여한 경우에는 당뇨가 유발되었음에도 불구하고 체중 증가의 현상이 나타났고, 장기 비대 현상은 억제 되고 있었다. 혈청 중성지방 몇 간의 총 콜레스테롤 함량도 현미 및 거대배아미 급여군에서 억제효과가 있었다. 그리고 대변으로 배설되는 총지질 및 콜레스테롤의 양도 거대배아미 급여군에서 대조군보다 유의하게 많은 것으로 나타났다. 이상의 결과들로부터 거대배아미 식이는 인슐린 의존형 당뇨쥐에서 대변중의 총 지질 및 총 콜레스테롤 배설량의 증가와 연관지어 당뇨병 모델의 체내 지질대사에 개선효과가 있음을 알 수 있다.

Keywords

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