Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of the Extract of Hoelen on Serum Lipid Profiles in Mice

복령 추출물이 혈중 지질성상에 미치는 영향

  • 윤희진 (울산대학교 생활과학대학 식품영양) ;
  • 차효미 (울산대학교 생활과학대학 식품영양) ;
  • 김성원 (울산대학교 생활과학대학 식품영양) ;
  • 신완철 (울산대학교 생활과학대학 식품영양) ;
  • 김혜경 (울산대학교 생활과학대학 식품영양) ;
  • 최석영 (울산대학교 생활과학대학 식품영양)
  • Published : 2006.08.30
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Abstract

The extracts of hoelen was evaluated for protective effects against the adverse effects of a high fat diet. Mice were divided into four groups; normal diet (control), high fat (HF) diet, high fat+water extract (HF+WE) and high fat+ethanol extract (HF+EE) and fed for 4 weeks. Food calorie consumptions were not significantly different between groups. Weight gain was significantly lower in HF+EE than the high fat group. Also, liver weight was significantly lower in HF+EE than the control group. The weight of epididymal fat tissue was 1.4 fold higher in high fat groups than control group. The concentration of serum triglyceride, total cholesterol and LDL-cholesterol increased in high fat group, but decreased by hoelen ethanol extract administration. Also serum HDL-cholesterol was decreased in the high fat group, but increased by the hoelen ethanol extract administration. Liver triglyceride and total cholesterol were not significantly different among groups. These data suggest that hoelen ethanol extract administration improves the serum lipid profiles of mice.

복령의 비만예방 및 개선효과에 대해 검토하기 위한 일환으로 복령추출물의 혈중 지질성상에 미치는 영향을 연구하였다. 마우스를 대조군, 고지방식이군(HF), 고지방식이+열수 추출물 첨가군(HF+WE), 고지방식이+에탄올 추출물 첨가군(HF+EE) 네 군으로 나누어 각각 4주간 투여하였다. 사료섭취량은 대조군, 고지방식이군 및 추출물 첨가군에서 유의 있는 차이가 없었다. 체중증가량은 대조군, 고지방식이군 및 열수 추출물 첨가군에서 유의 있는 차이는 없었으나, 에탄올 첨가군(HF+EE)에서 체중증가가 낮게 나타났다. 또한 대조군 및 고지방식이 투여군에 비해 HF+EE군에서 간 중량도 감소하였다. 그러나 부고환 지방조직 중량은 대조군에 비해 고지방식이군 및 추출물 첨가군 모두 약 1.4배 증가하였다. 혈중 트리글리세리드, 총 콜레스테롤 함량은 고지방식이군에서 증가하였는데, 에탄올 추출물 첨가군에서 유의 있게 감소하였다. 혈중 LDL-콜레스테롤은 고지방식이군에서 크게 증가하는데, 에탄올 추출물 첨가군에서 감소하였다. 또한 혈중 HDL-콜레스테롤 함량은 고지방식이군에서 감소하는데, 에탄올 추출물 첨가군에서 증가하였다. 간의 트리글리세리드 및 콜레스테롤 함량은 실험군 간에 유의 있는 차이를 보이지 않았다. 이상의 결과는 복령의 에탄올 추출물 투여로 고지방식이 투여로 인한 마우스의 혈중 지방분포를 개선할 수 있음을 제시해주고 있다.

Keywords

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