Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Hair Growth Promotion Effect of a Bio-Active Shampoo, Bonogen in C57BL/6 Mice

C57BL/6 마우스에서 기능성 샴푸 Bonogen의 양모 촉진 효과

  • Hong, Jin-Tae (College of Pharmacy Chungbuk National University) ;
  • Lee, Se-Ra (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Hwan-Hee (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Jo, Young-Kwang (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Baek, In-Jeoung (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Yon, Jung-Min (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Nahm, Sang-Seop (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Kwack, Dong-Hoon (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Lee, Jung-Eun (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Lee, Beom-Jun (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Yun, Young-Won (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Cheol-Jung (Gilmech Co., LTD.) ;
  • Nam, Sang-Yoon (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
  • 홍진태 (충북대학교 약학대학) ;
  • 이세라 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 김환희 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 조영광 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 백인정 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 연정민 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 남상섭 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 곽동훈 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 이정은 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 이범준 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 윤영원 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 김철정 ((주) 길맥) ;
  • 남상윤 (충북대학교 수의과대학 및 동물의학연구소)
  • Published : 2006.09.30
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Abstract

Bonogen shampoo is composed of several plant extracts which are known to be used in oriental medicine. This study was carried out to investigate the effects of Bonogen shampoo on hair growth in an alopecia model of C57BL/6 mice. There were eight male and female experimental groups including distilled water(DW: negative control), a commercial shampoo[M], 3% minoxidil (MXD) and Bonogen shampoo(BNG). Dorsal skin hair of six-week-old mice was trimmed with an electric clipper carefully not to damage the skin. The next day, mice without skin scratch were selected, randomized and separated in 10 mice per group. The test compounds were topically treated with 0.15 ml per mouse or dorsal skin for 21 days daily and then washed thoroughly with DW. The hair regrowth was determined photographically at 0, 4, 7, 10, 15, 18, and 21 days and histologically at day 21. No clinical signs were observed in all mice. Although body weight was slightly increased in 3% MXD group than other groups, it was not significant. Hair regrowth began to be promoted after 14 days and appeared a distinct regrowth pattern in all animals by topical treatment of test compounds at 18 days. In particular, the topical treatment of bonogen shampoo or 3% MXD for 21 days to dorsal skin accelerated hair regrowth faster than DW or M shampoo. At 21 days, the hair regrowth promotion speed was in order of 3% MXD>BNG>M>DW. The bonogen shampoo or 3% MXD also promoted hair follicle elongation compared to the negative control. These results suggest that bonogen shampoo has hair growth promoting activities and may be useful for treatment of bald or alopecia.

Keywords

References

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