Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Fasting Serum Glucose Level and Gastric Cancer Risk in a Nested Case-control Study

공복 혈당과 위암 발생 위험에 관한 코호트 내 환자-대조군 연구

  • Jun, Jae-Kwan (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Gwack, Jin (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Park, Sue-Kyung (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Choi, Yun-Hee (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Kim, Yeon-Ju (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Shin, Ae-Sun (Center for Health Services Research, Vanderbilt University Medical Center) ;
  • Chang, Soung-Hoon (Department of Preventive Medicine, College of Medicine, Konkuk University) ;
  • Shin, Hai-Rim (Research Institute for National Cancer Control and Evaluation, National Cancer Center) ;
  • Yoo, Keun-Young (Department of Preventive Medicine, Seoul National University College of Medicine,National Cancer Center)
  • 전재관 (서울대학교 의과대학 예방의학교실) ;
  • 곽진 (서울대학교 의과대학 예방의학교실) ;
  • 박수경 (서울대학교 의과대학 예방의학교실) ;
  • 최윤희 (서울대학교 의과대학 예방의학교실) ;
  • 김연주 (서울대학교 의과대학 예방의학교실) ;
  • 신애선 (반더빌트대학교 의과대학) ;
  • 장성훈 (건국대학교 의과대학 예방의학교실) ;
  • 신해림 (국립암센터 국가암관리사업지원평가연구단) ;
  • 유근영 (서울대학교 의과대학 예방의학교실, 국립암센터)
  • Published : 2006.11.30
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Abstract

Objectives : Diabetes has been reported as a risk factor for several cancers. However, the association between diabetes and gastric cancer has been inconsistent. The aim of this study was to evaluate the association between the fasting serum glucose level and gastric cancer risk in Korea. Methods : Among the members of the Korean Multi-Center Cancer Cohort (KMCC) from 1993 to 2004, a total of 100 incident gastric cancer cases were ascertained until December 31, 2002 and 400 controls were matched according to age, sex, and year and area of enrollment. Of the eligible subjects, those without fasting serum glucose level information were excluded, with a total of 64 cases and 236 controls finally selected. On enrollment, all subjects completed a baseline demographic and lifestyle characteristics questionnaire, and had their fasting serum glucose level measured. The Helicobacter pylori infection status was determined by an immunoblot assay using long-term stored serum. The odds ratios (ORs) were estimated using conditional and unconditional logistic regression models adjusted for the H. pylori infection status, smoking, drinking, education, follow-up period and matching variables. Results : The ORs for risk of gastric cancer according to the serum glucose level were 1.33 [95% CI=0.50-3.53] and 1.66 [95% CI=0.55-5.02] for the categories of 100-125 and 126 mg/dL or greater, respectively, compared to the category of less than 100 mg/dL. No increased risk of gastric cancer according to the serum glucose level was found (p-trend=0.337). Conclusions : This study provides no evidence for an association of the serum glucose level with gastric cancer.

Keywords

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