Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
권호 표지

The Relationship between ACE I/D Polymorphism and HDL Cholesterol

ACE 삽입 및 결손 유전자 다형성과 HDL 콜레스테롤과의 관련성

  • You, Chang-Hun (Department of Preventive Medicine and Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong-A University) ;
  • Kwak, Jong-Young (Medical Research Center for Cancer Molecular Therapy and Department of Biochemistry, College of Medicine, Dong-A University) ;
  • Kim, Na-Young (Department of Preventive Medicine and Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong-A University) ;
  • Roh, Mee-Sook (Department of Pathology and Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong-A University) ;
  • Jung, Kap-Yeol (Department of Occupational Medicine, Dong-A University Medical Center) ;
  • Lee, Yong-Hwan (Department of Preventive Medicine, Medical College, Kosin University) ;
  • Kim, Jung-Man (Department of Preventive Medicine and Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong-A University) ;
  • Kim, Joon-Youn (Department of Preventive Medicine and Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong-A University) ;
  • Hong, Young-Seoub (Department of Preventive Medicine and Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong-A University)
  • 유창훈 (동아대학교 의과대학 예방의학교실 및 암분자치료연구센터) ;
  • 곽종영 (동아대학교 의과대학 생화학교실 및 암분자치료연구센터) ;
  • 김나영 (동아대학교 의과대학 예방의학교실 및 암분자치료연구센터) ;
  • 노미숙 (동아대학교 의과대학 병리학교실 및 암분자치료연구센터) ;
  • 정갑열 (동아대학교 의과대학 산업의학교실) ;
  • 이용환 (고신대학교 의과대학 예방의학교실) ;
  • 김정만 (동아대학교 의과대학 예방의학교실 및 암분자치료연구센터) ;
  • 김준연 (동아대학교 의과대학 예방의학교실 및 암분자치료연구센터) ;
  • 홍영습 (동아대학교 의과대학 예방의학교실 및 암분자치료연구센터)
  • Published : 2006.11.30
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Abstract

Objectives : The purpose of this study is to evaluate the association of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with cardiovascular disease risk factors. Methods : Out of a total of 608 middle-aged adults who visited local health centers, 424 subjects (104 male, 320 female) who had not been diagnosed with hypertension, diabetes mellitus, or hyperlipidemia were included in this study. ACE genotypes were determined in all subjects by polymerase chain reaction methods. Results : Statistical differences in high-density lipoprotein (HDL) cholesterol levels according to ACE genotype were observed using ANOVA (p<0.05), but no differences were found in other cardiovascular risk factors. Specifically, men with the DD and DI genotypes had significantly lower HDL cholesterol levels than those with the 11 genotype based on the LSD multi-comparison test (p<0.05). Conclusions : In men, the D-allele of the ACE I/D polymorphism was significantly associated with reduced HDL cholesterol levels. In the future, larger studies are needed to confirm this relationship between ACE I/D polymorphism and HDL cholesterol.

Keywords

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