Nutritional Sciences

The Korean Nutrition Society (한국영양학회)
권호 표지

Effect of FC-GT Supplement on Body Fat and Lipid Metabolism in Rats

  • Woo, Myoung-Nam (Department of Food Science and Nutrition, Kyungpook National University) ;
  • Jeon, Seon-Min (Institute of Genetic Engineering, Kyungpook National University) ;
  • Kim, Hye-Jin (Department of Food Science and Nutrition, Kyungpook National University) ;
  • Yeo, Ji-Young (Department of Food Science and Nutrition, Kyungpook National University) ;
  • Ha, Tae-Youl (Food Function Research Division, Korea Food Research Institute) ;
  • Choi, Myung-Sook (Department of Food Science and Nutrition, Kyungpook National University)
  • Published : 2006.11.30
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Abstract

The objective of this study was to investigate the effects of supplementation of an antiobese functional formula (FC-GT) on body weight and lipid metabolism in rats fed a high-fat diet. Three groups of male Sprague-Dawley rats were fed different diets for 6 weeks: normal control (NC), high-fat (HF), and high-fat supplemented with powdered antiobese functional formula (FC-GT) (5% wt/wt) groups. Although body weight was not significantly different among the groups, relative weights of epididymal and perirenal white adipose tissues were significantly lower in the FC-GT group than in the HF group. FC-GT supplementation significantly lowered the plasma total cholesterol and triglyceride concentrations, whereas it elevated the ratio of HDL-C/total-C and improved the atherogenic index. Hepatic cholesterol and triglyceride concentrations were significantly lowered in the FC-GT group compared to the HF group. The accumulation of hepatic lipid droplets and the epididymal white adipocyte size of the FC-GT group were diminished compared to the HF group. Hepatic HMG-CoA reductase activity was significantly lower in the FC-GT group than in the HF group. Plasma GPT activity was significantly lowered in the FC-GT group compared to the HF group. Additionally, fecal weight was significantly increased in the FC-GT group than in the HF group. In addition, contents of fecal triglyceride and cholesterol were significantly higher in the FC-GT group compared to the other groups. The antioxidant activities of hepatic SOD, CAT, and GR were significantly increased in the FC-GT group compared to the HF group. Hepatic mARS and plasma mARS levels were significantly lowered in the FC-GT group compared to the NC group. Accordingly, we conclude that supplementation of FC-GT improves plasma and hepatic lipid levels in high-fat fed rats.

Keywords

References

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